CLCN3 (NM_001829) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC214128L3V

  • LentiORF®

Lenti ORF particles, CLCN3 (Myc-DDK-tagged)-Human chloride channel 3 (CLCN3), transcript variant b, 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP

Lentiviral Particles: DDK w/ Puro mGFP w/ Puro


Buy this product and get 50% off on the Lenti RapidTiter kit. Use Code: Rapid50

USD 1,374.00

7 Weeks*

Size
    • 200 ul

Product Images

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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Symbol CLCN3
Synonyms ClC-3; CLC3
Mammalian Cell Selection Puromycin
Vector pLenti-C-Myc-DDK-P2A-Puro
ACCN NM_001829
ORF Size 2454 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC214128).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001829.2
RefSeq Size 3982 bp
RefSeq ORF 2457 bp
Locus ID 1182
UniProt ID P51790
Cytogenetics 4q33
Domains CBS, voltage_CLC
Protein Families Druggable Genome, Ion Channels: Other, Transmembrane
MW 90.8 kDa
Gene Summary This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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