CD163 (NM_004244) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC208557L4V

Lenti ORF particles, CD163 (mGFP-tagged) - Human CD163 molecule (CD163), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC208557L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC208557L4V particle to overexpress human CD163-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: CD163
• Synonyms: M130; MM130; SCARI1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_004244
• ORF Size: 3468 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208557).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_004244.3
• RefSeq Size: 4190 bp
• RefSeq ORF: 3471 bp
• Locus ID: 9332
• UniProt ID: Q86VB7
• Cytogenetics: 12p13.31
• Domains: SR
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• MW: 125.4 kDa
• Gene Summary: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]