BMI1 (NM_005180) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC202871L1V

Lenti ORF particles, BMI1 (Myc-DDK tagged) - Human BMI1 polycomb ring finger oncogene (BMI1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: BMI1
• Synonyms: flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_005180
• ORF Size: 978 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202871).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_005180.5
• RefSeq Size: 3435 bp
• RefSeq ORF: 981 bp
• Locus ID: 648
• UniProt ID: P35226
• Cytogenetics: 10p12.2
• Domains: RING
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
• MW: 36.9 kDa
• Gene Summary: This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]