Neurl1a (NM_001163480) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR217666L3V

Lenti ORF particles, Neurl1a (Myc-DDK-tagged) - Mouse neuralized homolog 1A (Drosophila) (Neurl1a), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Neurl1a
• Synonyms: 2410129E16Rik; AI450910; AI481072; Neu1; Neur1; Neurl; Neurl1; Nlz; Rnf67
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_001163480
• ORF Size: 1671 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR217666).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001163480.1, NP_001156952.1
• RefSeq Size: 3690 bp
• RefSeq ORF: 1674 bp
• Locus ID: 18011
• UniProt ID: Q923S6
• Cytogenetics: 19 39.39 cM
• Gene Summary: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.[UniProtKB/Swiss-Prot Function]