CLC7 (CLCN7) (NM_001287) Human Untagged Clone

CAT#: SC320367

CLCN7 (untagged)-Human chloride channel 7 (CLCN7), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLC7
• Synonyms: CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001287.3 CCGGCGCTTCCCGGCCGGTGTCGCTCCGCGGCGGGCCATGGCCAACGTCTCTAAGAAGGT
  GTCCTGGTCCGGCCGGGACCGGGACGACGAGGAGGCGGCGCCGCTGCTGCGGAGGACGGC
  GCGGCCCGGCGGGGGGACGCCGCTGCTGAACGGGGCTGGGCCTGGGGCTGCGCGCCAGTC
  ACCACGTTCTGCGCTTTTCCGAGTCGGACATATGAGCAGCGTGGAGCTGGATGATGAACT
  TTTGGACCCGGATATGGACCCTCCACATCCCTTCCCCAAGGAGATCCCACACAACGAGAA
  GCTCCTGTCCCTCAAGTATGAGAGCTTGGACTATGACAACAGTGAGAACCAGCTGTTCCT
  GGAGGAGGAGCGGCGGATCAATCACACGGCCTTCCGGACGGTGGAGATCAAGCGCTGGGT
  CATCTGCGCCCTCATTGGGATCCTCACGGGCCTCGTGGCCTGCTTCATTGACATCGTGGT
  GGAAAACCTGGCTGGCCTCAAGTACAGGGTCATCAAGGGCAATATCGACAAGTTCACAGA
  GAAGGGCGGACTGTCCTTCTCCCTGTTGCTGTGGGCCACGCTGAACGCCGCCTTCGTGCT
  CGTGGGCTCTGTGATTGTGGCTTTCATAGAGCCGGTGGCTGCTGGCAGCGGAATCCCCCA
  GATCAAGTGCTTCCTCAACGGGGTGAAGATCCCCCACGTGGTGCGGCTCAAGACGTTGGT
  GATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGG
  GCCGATGATCCACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGAAGGTCAACGTC
  ACTGAAACGAGATTTCAAGATCTTCGAGTACTTCCGCAGAGACACAGAGAAGCGGGACTT
  CGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCCGTGGGTGGGGT
  CCTGTTCAGCTTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGATCTT
  CTTTGCTTCCATGATCTCCACGTTCACCCTGAATTTTGTTCTGAGCATTTACCACGGGAA
  CATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAAT
  GGCCTACACGATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCT
  TGGAGCAGTGTTCAATGCCTTGAACTACTGGCTGACCATGTTTCGAATCAGGTACATCCA
  CCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACGGCCACAGTTGC
  CTTCGTGCTGATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGCTCCATGTCCTA
  CCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTACAACTCCATGGCTGCGGCCTTCTTCAA
  CACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCT
  GACCCTCGGCCTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCAC
  GGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCTCATCGGGGCTGCCTGGGGCCGGCTCTT
  TGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCCGGCAAATACGC
  CCTGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGT
  CATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTCCCCATCATGCTGGTGCTCAT
  GACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCT
  GCAGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAG
  GGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGTGAGAAGGTCGGCGTCATTGT
  GGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGA
  TGACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCT
  AAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTGGTACAGCGGCGCCTGAGGCT
  GAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCA
  GGACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGT
  GCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAAGCTGTTCCGGGCCCTGGGCCTGCGGCA
  CCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGC
  CAGGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCC
  AGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGCCCTTCTGCATTTCCTCCCGGA
  GTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCA
  GCTGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGG
  GCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCCAGCCTCCACTCTCCTCGTCTA
  GGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCC
  TCTTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGA
  GCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCTGCCCTGGAAGGGCCCCTCTGCCTCC
  ACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGA
  CGGCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGA
  CCGCCCCGGAGAGCAGCTTCACACTGGCGCCACAGAGGAGCCCCACGTGCACTCCCCGGC
  CTGCATCCGGCTTGGGTACACGGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTG
  TGATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTG
  GTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACACCCAGCCCTGCCTTGGTCCCTG
  AGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCT
  AGCACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCTTGCCCCTGCCAGCCACCAA
  GCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAGAGGACACCTGGCCCAGCACAG
  GCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGC
  CCCTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACG
  GGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAGCAACACGGGTCCCTCCGTGGGGGGC
  TGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGA
  CGCCACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAA
  CGCGAAATAAAGAAATCCTCTCAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_001287
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001287.3, NP_001278.1
• RefSeq Size: 3760 bp
• RefSeq ORF: 2418 bp
• Locus ID: 1186
• UniProt ID: P51798
• Cytogenetics: 16p13.3
• Domains: CBS, voltage_CLC
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Gene Summary: The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.