Caspr2 (CNTNAP2) (NM_014141) Human Untagged Clone

CAT#: SC115167

CNTNAP2 (untagged)-Human contactin associated protein-like 2 (CNTNAP2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Caspr2
• Synonyms: AUTS15; CASPR2; CDFE; NRXN4; PTHSL1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115167 sequence for NM_014141 edited (data generated by NextGen Sequencing)
  ATGCAGGCGGCTCCGCGCGCCGGCTGCGGGGCAGCGCTCCTGCTGTGGATTGTCAGCAGC
  TGCCTCTGCAGAGCCTGGACGGCTCCCTCCACGTCCCAAAAATGTGATGAGCCACTTGTC
  TCTGGACTCCCCCATGTGGCTTTCAGCAGCTCCTCCTCCATCTCTGGTAGCTATTCTCCC
  GGCTATGCCAAGATAAACAAGAGAGGAGGTGCTGGGGGATGGTCTCCATCAGACAGCGAC
  CATTATCAATGGCTTCAGGTTGACTTTGGCAATCGGAAGCAGATCAGTGCCATTGCAACC
  CAAGGAAGGTATAGCAGCTCAGATTGGGTGACCCAATACCGGATGCTCTACAGCGACACA
  GGGAGAAACTGGAAACCCTATCATCAAGATGGGAATATCTGGGCATTTCCCGGAAACATT
  AACTCTGACGGTGTGGTCCGGCACGAATTACAGCATCCGATTATTGCCCGCTATGTGCGC
  ATAGTGCCTCTGGATTGGAATGGAGAAGGTCGCATTGGACTCAGAATTGAAGTTTATGGC
  TGTTCTTACTGGGCTGATGTTATCAACTTTGATGGCCATGTTGTATTACCATATAGATTC
  AGAAACAAGAAGATGAAAACACTGAAAGATGTCATTGCCTTGAACTTTAAGACGTCTGAA
  AGTGAAGGAGTAATCCTGCACGGAGAAGGACAGCAAGGAGATTACATTACCTTGGAACTG
  AAAAAAGCCAAGCTGGTCCTCAGTTTAAACTTAGGAAGCAACCAGCTTGGCCCCATATAT
  GGCCACACATCAGTGATGACAGGAAGTTTGCTGGATGACCACCACTGGCACTCTGTGGTC
  ATTGAGCGCCAGGGGCGGAGCATTAACCTCACTCTGGACAGGAGCATGCAGCACTTCCGT
  ACCAATGGAGAGTTTGACTACCTGGACTTGGACTATGAGATAACCTTTGGAGGCATCCCT
  TTCTCTGGCAAGCCCAGCTCCAGCAGTAGAAAGAATTTCAAAGGCTGCATGGAAAGCATC
  AACTACAATGGCGTCAACATTACTGATCTTGCCAGAAGGAAGAAATTAGAGCCCTCAAAT
  GTGGGAAATTTGAGCTTTTCTTGTGTGGAACCCTATACGGTGCCTGTCTTTTTCAACGCT
  ACAAGTTACCTGGAGGTGCCCGGACGGCTTAACCAGGACCTGTTCTCAGTCAGTTTCCAG
  TTTAGGACATGGAACCCCAATGGTCTCCTGGTCTTCAGTCACTTTGCGGATAATTTGGGC
  AATGTGGAGATTGACCTCACTGAAAGCAAAGTGGGTGTTCACATCAACATCACACAGACC
  AAGATGAGCCAAATCGATATTTCCTCAGGTTCTGGGTTGAATGATGGACAGTGGCACGAG
  GTTCGCTTCCTAGCCAAGGAAAATTTTGCTATTCTCACCATCGATGGAGATGAAGCATCA
  GCAGTTCGAACTAATAGTCCCCTTCAAGTTAAAACTGGCGAGAAGTACTTTTTTGGAGGT
  TTTCTGAACCAGATGAATAACTCAAGTCACTCTGTCCTTCAGCCTTCATTCCAAGGATGC
  ATGCAGCTCATTCAAGTGGACGATCAACTTGTAAATTTATACGAAGTGGCACAAAGGAAG
  CCGGGAAGTTTCGCGAATGTCAGCATTGACATGTGTGCGATCATAGACAGATGTGTGCCC
  AATCACTGTGAGCATGGTGGAAAGTGCTCGCAAACATGGGACAGCTTCAAATGCACTTGT
  GATGAGACAGGATACAGTGGGGCCACCTGCCACAACTCTATCTACGAGCCTTCCTGTGAA
  GCCTACAAACACCTAGGACAGACATCAAATTATTACTGGATAGATCCTGATGGCAGCGGA
  CCTCTGGGGCCTCTGAAAGTTTACTGCAACATGACAGAGGACAAAGTGTGGACCATAGTG
  TCTCATGACTTGCAGATGCAGACGCCTGTGGTCGGCTACAACCCAGAAAAATACTCAGTG
  ACACAGCTCGTTTACAGCGCCTCCATGGACCAGATAAGTGCCATCACTGACAGTGCCGAG
  TACTGCGAGCAGTATGTCTCCTATTTCTGCAAGATGTCAAGATTGTTGAACACCCCAGAT
  GGAAGCCCTTACACTTGGTGGGTTGGCAAAGCCAACGAGAAGCACTACTACTGGGGAGGC
  TCTGGGCCTGGAATCCAGAAATGTGCCTGCGGCATCGAACGCAACTGCACAGATCCCAAG
  TACTACTGTAACTGCGACGCGGACTACAAGCAATGGAGGAAGGATGCTGGTTTCTTATCG
  TACAAAGATCACCTGCCAGTGAGCCAAGTGGTGGTTGGAGATACTGACCGTCAAGGCTCA
  GAAGCCAAATTGAGCGTAGGTCCTCTGCGCTGCCAAGGAGACAGGAATTATTGGAATGCC
  GCCTCTTTCCCAAACCCATCCTCCTACCTGCACTTCTCTACTTTCCAAGGGGAAACTAGC
  GCTGACATTTCTTTCTACTTCAAAACATTAACCCCCTGGGGAGTGTTTCTTGAAAATATG
  GGAAAGGAAGATTTCATCAAGCTGGAGCTGAAGTCTGCCACAGAAGTGTCCTTTTCATTT
  GATGTGGGAAATGGGCCAGTAGAGATTGTAGTGAGGTCACCAACCCCTCTCAACGATGAC
  CAGTGGCACCGGGTCACTGCAGAGAGGAATGTCAAGCAGGCCAGCCTACAGGTGGACCGG
  CTACCGCAGCAGATCCGCAAGGCCCCAACAGAAGGCCACACCCGCCTGGAGCTCTACAGC
  CAGTTATTTGTGGGTGGTGCTGGGGGCCAGCAGGGCTTCCTGGGCTGCATCCGCTCCTTG
  AGGATGAATGGGGTGACACTTGACCTGGAGGAAAGAGCAAAGGTCACATCTGGGTTCATA
  TCCGGATGCTCGGGCCATTGCACCAGCTATGGAACAAACTGTGAAAATGGAGGCAAATGC
  CTAGAGAGATACCACGGTTACTCCTGCGATTGCTCTAATACTGCATATGATGGAACATTT
  TGCAACAAAGATGTTGGTGCATTTTTTGAAGAAGGGATGTGGCTACGATATAACTTTCAG
  GCACCAGCAACAAATGCCAGAGACTCCAGCAGCAGAGTAGACAACGCTCCCGACCAGCAG
  AACTCCCACCCGGACCTGGCACAGGAGGAGATCCGCTTCAGCTTCAGCACCACCAAGGCG
  CCCTGCATTCTCCTCTACATCAGCTCCTTCACCACAGACTTCTTGGCAGTCCTCGTCAAA
  CCCACTGGAAGCTTACAGATTCGATACAACCTGGGTGGCACCCGAGAGCCATACAATATT
  GACGTAGACCACAGGAACATGGCCAATGGACAGCCCCACAGTGTCAACATCACCCGCCAC
  GAGAAGACCATCTTTCTCAAGCTCGATCATTATCCTTCTGTGAGTTACCATCTGCCAAGT
  TCATCCGACACCCTCTTCAATTCTCCCAAGTCGCTCTTTCTGGGAAAAGTTATAGAAACA
  GGGAAAATTGACCAAGAGATTCACAAATACAACACCCCAGGATTCACTGGTTGCCTCTCC
  AGAGTCCAGTTCAACCAGATCGCCCCTCTCAAGGCCGCCTTGAGGCAGACAAACGCCTCG
  GCTCACGTCCACATCCAGGGCGAGCTGGTGGAGTCCAACTGCGGGGCCTCGCCGCTGACC
  CTCTCCCCCATGTCGTCCGCCACCGACCCCTGGCACCTGGATCACCTGGATTCAGCCAGT
  GCAGATTTTCCATATAATCCAGGACAAGGCCAAGCTATAAGAAATGGAGTCAACAGAAAC
  TCGGCTATCATTGGAGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGCACCCTGGTC
  TTCCTGATCCGGTACATGTTCCGCCACAAGGGCACCTACCATACCAACGAAGCAAAGGGG
  GCGGAGTCGGCAGAGAGCGCGGACGCCGCCATCATGAACAACGACCCCAACTTCACAGAG
  ACCATTGATGAAAGCAAAAAGGAATGGCTCATTTGA
  
  Clone variation with respect to NM_014141.5
  2280 a=>g;3723 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014141 unedited
  NNGGCGTTCATCATTTGTNATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGCCT
  CCCTCCCCCGTCCTTTGGTGATTTTTTTTTTTCAAAAAGGAGAAGGCGGGGTAGGTGTCC
  GTTCCCTCCCCTCTTCCCCCTCCTTTGCCTTCTTGGTTTGAATTTCCTCCCCCGGCGTTG
  CACTGGCACACAGTGCAAGAGGCAATACCCGCACTGAGGGAGAACGAAGGCTGAGACTCC
  CCTGCCGCTCCAAGCCCGGAAGAACTGGAGCCTGGAGGGGGGTGAGGGGAGAAGAGGAAG
  CGGGAGGAGCTTGGCTTCCTCGCGTATTTGAGGACAGCCCATCTCCCTTCAAGAACCCTA
  CGGAGAGTCGGACTGCATCTCCGCAGCGAGCTCTTGGAGCGCCGCCGGCCGGGAGGCGAA
  GGATGCAGGCGGCTCCGCGCGCCGGCTGCGGNGCAGCGCTCCTGCTGTGGATTGTCAGCA
  GCTGCCTCTGCAGAGCCTGGACGGCTCCCTCCACGTCCCAAANATGTGATGAGCCACTTG
  TCTCTGGACTCCCCCATGTGGCTTTCAGCAGCTCCTCCTCCATCTCTGGTAGCTATTCTC
  CCGGCTATGCCCAGATAAAACAGAAAAGAGGTGCCTGGGGGATGGGTCTCATCAGACAGC
  GACCATTATCAATGGCTTCANGTTTGACTTTGGCAATCGAAAGCAGATCAGTGCCCTTTG
  CAACCCAAGGAAAGTATAGCAGCTCAGATTGGGTGACCCAATAACCGGATGCTCTACAGC
  GACCCAGGGAGAACCTGGAAACCCCTATCATCAGATGGGAATTATCTGGGCCTTTTCCGG
  AAACATTAACTCTGACCGTGTGGTTCGGCCCCATTTACAGCTCCCATTATTGCCCGCTTT
  GTC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014141 unedited
  CTTGGCCGCGGCCGCAATCTANGTCGAGTTTTTTTTTTTTTTTTTTGTGATCAGTCTCAA
  GAATATTCCATTATATTCCATTGCCTGCCTCCCCCAACTTGTGCTGATATTTTAAGGATG
  TGCTCAAGAGTATGAAGCAGGGTGCTTTTGTCCCTTTCTCTCCTCCCTAGTAATTCCCTC
  CTCCCTATCCCATAGCCAAGTAGCCACCCCTCAAATGAGCCATTCCTTTTTGCTTTCATC
  AATGGTCTCTGTGAAGTTGGGGTCGTTGTTCATGATGGCGGCGTCCGCGCTCTCTGCCGA
  CTCCGCCCCCTTTGCTTCGTTGGTATGGTAGGTGCCCTTGTGGCGGAACATGTACCGGAT
  CAGGAAGACCAGGGTGCACAGGATGGTGAAAATCACCACAGCAATGACGCCTCCAATGAT
  AGCCGAGTTTCTGTTGACTCCATTTCTTATAGCTTGGCCTTGTCCTGGATTATATGGAAA
  ATCTGCACTGGCTGAATCCAGGTGATCCAGGTGCCAGGGGTCGGTGGCGGACGACATGGG
  GGAGAGGGTCAGCGGCGAGGCCCCGCAGTTGGACTCCACCAGCTCGCCCTGGATGTGGAC
  GTGAGCCGAGGCGTTTGTCTGCCTCAAGGCGGNCTTGAGAGGGGCGATCTGGTTGAACTG
  GACTCTGGAGAGGCAACCAGTGAATCCTGGGGTGTTGTATTTGTGAATCTCTTGGTCAAT
  TTTCCCTGTTTCTATAACTTTTTCCAGAAAGAGCGACTTGGGAGAAATGAAGAGGGTGTC
  GGATGAACTGGGCAGATGGGAACTCACAGAAGGATAATGATCGAGCTTGAGCAAAGAGGT
  CTTCTCGTGGCGGTTGATGTTGACACTGGGGGGCTGTCCATTGGCCCTGGTCCCTGGGGC
  TAACCACATATTGGATGCCTCTCGGNGGCACCCCAGTTGGATCGCATCTGTAAGCTTCCG
  GGGTTTTCACAGGCACGCCAAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014141
• Insert Size: 4230 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_014141.3, NP_054860.1
• RefSeq Size: 8107 bp
• RefSeq ORF: 3996 bp
• Locus ID: 26047
• UniProt ID: Q9UHC6
• Cytogenetics: 7q35-q36.1
• Domains: F5_F8_type_C, LamG, EGF
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)
• Gene Summary: This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability. [provided by RefSeq, Jul 2017]