Melatonin Related Receptor(GPR50) (NM_004224) Human Tagged ORF Clone

CAT#: RG217839

Specifications

Product Data

• Product Name: Melatonin Related Receptor(GPR50) (NM_004224) Human Tagged ORF Clone
• Symbol: GPR50
• Synonyms: H9; Mel1c
• Vector: pCMV6-AC-GFP
• Sequence Data:
  ORF Nucleotide Sequence

  >RG217839 representing NM_004224
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGGCCCACCCTAGCGGTTCCCACCCCCTATGGCTGTATTGGCTGTAAGCTACCCCAGCCAGAATACC
  CACCGGCTCTAATCATCTTTATGTTCTGCGCGATGGTTATCACCATCGTTGTAGACCTAATCGGCAACTC
  CATGGTCATTTTGGCTGTGACGAAGAACAAGAAGCTCCGGAATTCTGGCAACATCTTCGTGGTCAGTCTC
  TCTGTGGCCGATATGCTGGTGGCCATCTACCCATACCCTTTGATGCTGCATGCCATGTCCATTGGGGGCT
  GGGATCTGAGCCAGTTACAGTGCCAGATGGTCGGGTTCATCACAGGGCTGAGTGTGGTCGGCTCCATCTT
  CAACATCGTGGCAATCGCTATCAACCGTTACTGCTACATCTGCCACAGCCTCCAGTACGAACGGATCTTC
  AGTGTGCGCAATACCTGCATCTACCTGGTCATCACCTGGATCATGACCGTCCTGGCTGTCCTGCCCAACA
  TGTACATTGGCACCATCGAGTACGATCCTCGCACCTACACCTGCATCTTCAACTATCTGAACAACCCTGT
  CTTCACTGTTACCATCGTCTGCATCCACTTCGTCCTCCCTCTCCTCATCGTGGGTTTCTGCTACGTGAGG
  ATCTGGACCAAAGTGCTGGCGGCCCGTGACCCTGCAGGGCAGAATCCTGACAACCAACTTGCTGAGGTTC
  GCAATTTTCTAACCATGTTTGTGATCTTCCTCCTCTTTGCAGTGTGCTGGTGCCCTATCAACGTGCTCAC
  TGTCTTGGTGGCTGTCAGTCCGAAGGAGATGGCAGGCAAGATCCCCAACTGGCTTTATCTTGCAGCCTAC
  TTCATAGCCTACTTCAACAGCTGCCTCAACGCTGTGATCTACGGGCTCCTCAATGAGAATTTCCGAAGAG
  AATACTGGACCATCTTCCATGCTATGCGGCACCCTATCATATTCTTCTCTGGCCTCATCAGTGATATTCG
  TGAGATGCAGGAGGCCCGTACCCTGGCCCGCGCCCGTGCCCATGCTCGCGACCAAGCTCGTGAACAAGAC
  CGTGCCCATGCCTGTCCTGCTGTGGAGGAAACCCCGATGAATGTCCGGAATGTTCCATTACCTGGTGATG
  CTGCAGCTGGCCACCCCGACCGTGCCTCTGGCCACCCTAAGCCCCATTCCAGATCCTCCTCTGCCTATCG
  CAAATCTGCCTCTACCCACCACAAGTCTGTCTTTAGCCACTCCAAGGCTGCCTCTGGTCACCTCAAGCCT
  GTCTCTGGCCACTCCAAGCCTGCCTCTGGTCACCCCAAGTCTGCCACTGTCTACCCTAAGCCTGCCTCTG
  TCCATTTCAAGGCTGACTCTGTCCATTTCAAGGGTGACTCTGTCCATTTCAAGCCTGACTCTGTTCATTT
  CAAGCCTGCTTCCAGCAACCCCAAGCCCATCACTGGCCACCATGTCTCTGCTGGCAGCCACTCCAAGTCT
  GCCTTCAGTGCTGCCACCAGCCACCCTAAACCCACCACTGGCCACATCAAGCCAGCTACCAGCCATGCTG
  AGCCCACCACTGCTGACTATCCCAAGCCTGCCACTACCAGCCACCCTAAGCCCACTGCTGCTGACAACCC
  TGAGCTCTCTGCCTCCCATTGCCCCGAGATCCCTGCCATTGCCCACCCTGTGTCTGACGACAGTGACCTC
  CCTGAGTCGGCCTCTAGCCCTGCCGCTGGGCCCACCAAGCCTGCTGCCAGCCAGCTGGAGTCTGACACCA
  TCGCTGACCTTCCTGACCCTACTGTAGTCACTACCAGTACCAATGATTACCATGATGTCGTGGTTGTTGA
  TGTTGAAGATGATCCTGATGAAATGGCTGTG
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG217839 representing NM_004224
  Red=Cloning site Green=Tags(s)
  
  MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSL
  SVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIF
  SVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVR
  IWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAY
  FIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQD
  RAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP
  VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKS
  AFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDL
  PESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVVDVEDDPDEMAV
  
  TRTRRLE - GFP Tag - V
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• Tag: TurboGFP
• ACCN: NM_004224
• ORF Size: 1851 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data

• RefSeq: NM_004224.2, NP_004215
• RefSeq Size: 2010
• RefSeq ORF: 1854
• Locus ID: 9248
• Cytogenetics: Xq28
• Protein Families: GPCR, Transmembrane, Druggable Genome
• Protein Pathways: Neuroactive ligand-receptor interaction
• Gene Summary: This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010].

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