CTIP2 (BCL11B) (NM_001282238) Human Tagged ORF Clone
BCL11B (myc-DDK-tagged) - Human B-cell CLL/lymphoma 11B (zinc finger protein) (BCL11B), transcript variant 4
|Product Name||CTIP2 (BCL11B) (NM_001282238) Human Tagged ORF Clone|
|Type||Human Tagged ORF Clone|
|Synonyms||ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49; RIT1; ZNF856B|
|E. coli Selection||Kanamycin (25 ug/mL)|
|Restriction Sites||SgfI-RsrII Cloning Scheme for this gene Plasmid Map|
|ORF Size||2466 bp|
|OTI Disclaimer||The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info|
|OTI Annotation||This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.|
|Product Components||The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.|
|Reconstitution||1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
|RefSeq Size||7828 bp|
|RefSeq ORF||2469 bp|
|Protein Families||Druggable Genome|
|Gene Summary||This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]|
|The use of this cDNA Clones has been cited in the following citations:|
Increased expression of BCL11B and its recruited chromatin remodeling factors during highly active antiretroviral therapy synergistically represses the transcription of human immunodeficiency virus type 1 and is associated with residual immune activation
,Wang, J;Yang, Z;Wu, NP;Yang, J;,
Arch. Virol. 2019
,PubMed ID 31828511
|cDNA Clone Resources|
|SC337529||BCL11B (untagged) - Human B-cell CLL/lymphoma 11B (zinc finger protein) (BCL11B), transcript variant 4||