Notch3 (NM_008716) Mouse Tagged ORF Clone

CAT#: MR212149

Notch3 (Myc-DDK-tagged) - Mouse Notch gene homolog 3 (Drosophila) (Notch3)

Product Images

Circular map for MR212149

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Notch3
• Synonyms: AW229011; hpbk; N3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >MR212149 representing NM_008716
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGGCTGGGGGCCCGGGGCCGCCGCCGCCGTCGTCGCCTGATGGCCTTGCCACCGCCACCACCGCCCA
  TGCGGGCGCTGCCCCTGCTGCTGCTGCTAGCGGGGCTGGGGGCTGCAGCACCCCCTTGTCTGGATGGAAG
  CCCATGTGCAAATGGAGGTCGGTGCACCCACCAGCAGCCCTCCCTGGAGGCTGCTTGCCTGTGCCTGCCA
  GGCTGGGTGGGTGAGCGGTGCCAGCTGGAAGACCCTTGCCACTCAGGCCCTTGTGCTGGCCGAGGCGTTT
  GCCAGAGTTCAGTGGTGGCGGGCACCGCCCGATTCTCCTGTCGTTGTCTCCGTGGCTTCCAAGGCCCAGA
  CTGCTCCCAGCCAGACCCCTGCGTCAGCAGGCCCTGTGTTCATGGTGCCCCCTGCTCAGTGGGGCCGGAT
  GGCCGATTTGCCTGTGCCTGCCCACCTGGCTACCAGGGTCAAAGCTGCCAAAGTGACATAGATGAGTGCC
  GATCTGGTACAACTTGCCGTCATGGTGGTACCTGTCTCAATACACCTGGATCCTTCCGCTGCCAGTGTCC
  TCTTGGTTATACAGGGCTGCTGTGTGAGAACCCCGTAGTGCCCTGTGCCCCTTCCCCGTGTCGTAATGGT
  GGCACCTGTAGGCAGAGCAGTGATGTCACATATGACTGTGCTTGCCTTCCTGGCTTCGAGGGCCAGAACT
  GTGAAGTCAACGTGGATGACTGTCCTGGACATCGGTGTCTCAATGGGGGAACGTGTGTAGACGGTGTCAA
  TACTTACAACTGCCAGTGCCCTCCGGAGTGGACAGGCCAGTTCTGTACAGAAGATGTGGATGAGTGTCAG
  CTGCAGCCCAATGCCTGCCACAATGGGGGTACCTGCTTCAACCTACTGGGTGGCCACAGCTGTGTATGTG
  TCAATGGCTGGACGGGTGAGAGCTGCAGTCAGAATATCGATGACTGTGCTACAGCCGTGTGTTTCCATGG
  GGCCACCTGCCATGACCGTGTGGCCTCTTTCTACTGTGCCTGCCCTATGGGGAAGACAGGCCTCTTGTGT
  CATCTGGATGATGCATGTGTCAGCAACCCCTGCCATGAGGATGCTATCTGTGACACAAACCCTGTGAGTG
  GCCGGGCCATCTGCACCTGCCCACCTGGCTTCACTGGAGGGGCATGTGACCAGGATGTGGATGAGTGCTC
  GATTGGTGCCAACCCCTGTGAACATTTGGGTCGGTGTGTGAATACACAGGGCTCATTCTTGTGCCAATGT
  GGCCGTGGCTATACTGGACCTCGCTGTGAGACTGATGTCAATGAGTGTCTCTCCGGGCCCTGCCGCAACC
  AGGCCACGTGTCTTGACCGAATTGGCCAGTTTACTTGCATCTGCATGGCAGGCTTCACAGGGACCTACTG
  TGAGGTGGACATCGACGAATGTCAGAGCAGCCCATGTGTCAATGGTGGTGTCTGCAAGGACAGAGTCAAT
  GGCTTCAGCTGCACCTGCCCATCAGGATTCAGTGGGTCCATGTGTCAGCTGGATGTGGATGAGTGTGCAA
  GCACTCCCTGCCGGAATGGTGCCAAGTGTGTGGACCAGCCTGACGGCTATGAGTGTCGCTGTGCAGAGGG
  CTTTGAGGGCACTTTGTGTGAGCGAAACGTGGATGACTGCTCTCCGGATCCCTGCCACCACGGGCGCTGT
  GTCGATGGCATTGCTAGCTTCTCGTGTGCTTGTGCCCCAGGCTATACGGGCATACGCTGTGAGAGCCAGG
  TGGATGAGTGCCGCAGCCAGCCCTGTCGATATGGGGGCAAATGTCTAGACTTGGTGGACAAGTACCTCTG
  CCGTTGTCCTCCCGGAACCACAGGTGTGAACTGTGAAGTCAACATTGATGACTGTGCCAGTAACCCCTGT
  ACCTTTGGAGTTTGCCGTGATGGCATCAACCGTTATGACTGTGTCTGTCAGCCTGGATTCACAGGGCCCC
  TCTGCAACGTGGAGATCAATGAGTGTGCATCCAGCCCATGTGGAGAGGGTGGCTCCTGTGTGGATGGGGA
  AAATGGCTTCCACTGCCTCTGTCCACCTGGCTCCCTGCCTCCACTTTGCCTACCTGCGAACCATCCCTGT
  GCCCACAAGCCCTGTAGTCATGGAGTCTGCCATGATGCACCAGGCGGGTTCCGCTGTGTTTGTGAGCCCG
  GGTGGAGTGGCCCTCGCTGTAGCCAGAGCCTGGCTCCAGATGCCTGTGAGTCCCAGCCCTGCCAGGCTGG
  TGGCACCTGCACCAGTGATGGAATAGGCTTTCGCTGCACCTGTGCCCCTGGATTCCAGGGCCATCAGTGT
  GAGGTGCTGTCCCCCTGTACTCCAAGCCTCTGTGAGCACGGAGGCCACTGTGAGTCTGACCCTGACCGGC
  TGACTGTCTGTTCCTGTCCCCCAGGCTGGCAAGGCCCACGATGCCAGCAGGATGTGGATGAATGTGCCGG
  TGCCTCACCCTGCGGCCCCCATGGTACCTGCACCAACCTGCCAGGGAATTTCAGGTGCATCTGCCACAGG
  GGATACACTGGCCCCTTCTGTGATCAAGACATTGACGACTGTGACCCCAACCCGTGCCTCCATGGTGGCT
  CCTGCCAGGATGGCGTGGGCTCCTTTTCCTGTTCTTGCCTCGACGGCTTTGCTGGTCCTCGCTGTGCCCG
  AGATGTGGACGAATGTCTGAGCAGCCCCTGTGGCCCTGGCACCTGTACTGATCACGTGGCCTCCTTCACC
  TGTGCCTGTCCACCTGGTTATGGAGGCTTCCACTGTGAGATTGACTTGCCGGACTGCAGCCCCAGTTCCT
  GCTTCAATGGAGGGACCTGTGTGGATGGCGTGAGCTCCTTCAGCTGTCTGTGTCGCCCCGGCTACACAGG
  CACACACTGCCAATACGAGGCTGACCCCTGCTTTTCCCGGCCCTGTCTGCACGGGGGCATCTGCAACCCC
  ACCCACCCAGGATTTGAATGCACCTGCCGGGAGGGCTTCACTGGGAGTCAGTGTCAGAACCCAGTGGACT
  GGTGCAGCCAGGCACCCTGTCAGAATGGGGGTCGCTGTGTCCAGACTGGGGCTTACTGCATTTGTCCACC
  TGGATGGAGTGGCCGCCTGTGCGACATACAAAGCCTGCCCTGCACGGAGGCCGCAGCCCAGATGGGGGTG
  AGGTTGGAGCAGCTGTGTCAGGAAGGTGGAAAGTGCATAGACAAGGGCCGCTCCCACTACTGTGTGTGTC
  CAGAGGGCCGTACGGGTAGTCACTGTGAACACGAGGTGGATCCCTGCACGGCCCAGCCTTGCCAGCACGG
  GGGCACTTGCCGTGGTTACATGGGGGGCTATGTGTGTGAGTGTCCAGCTGGCTATGCTGGTGACAGTTGT
  GAGGATAATATAGATGAGTGTGCTTCCCAGCCCTGCCAGAACGGAGGCTCCTGTATCGATCTTGTGGCCC
  GCTATCTCTGTTCCTGTCCCCCTGGCACACTGGGAGTTCTCTGTGAGATCAATGAGGACGACTGTGACCT
  AGGCCCATCCTTGGACTCAGGCGTTCAGTGCCTACACAATGGCACCTGTGTGGACCTGGTGGGTGGCTTC
  CGCTGTAACTGTCCCCCAGGATACACAGGTCTGCACTGTGAGGCAGACATCAATGAGTGTCGCCCGGGTG
  CCTGCCATGCAGCGCATACTCGGGACTGCCTACAAGATCCAGGTGGGCATTTCCGCTGCGTCTGCCATCC
  TGGCTTCACAGGGCCTCGCTGTCAGATTGCTCTGTCCCCCTGTGAGTCCCAGCCATGTCAGCATGGAGGC
  CAGTGCCGTCACAGCCTAGGCCGTGGAGGTGGGCTGACCTTCACCTGTCACTGTGTCCCGCCATTCTGGG
  GTCTGCGTTGTGAGCGGGTGGCACGCTCTTGCCGAGAGCTGCAGTGCCCAGTGGGTATCCCATGCCAGCA
  GACAGCCCGTGGACCACGCTGCGCTTGTCCTCCGGGGCTGTCCGGGCCCTCCTGCCGGGTTTCTAGGGCG
  TCACCCTCAGGAGCTACTAACGCCAGCTGCGCCTCTGCCCCTTGTCTGCATGGGGGCTCATGCCTACCTG
  TACAGAGTGTCCCTTTCTTCCGCTGTGTGTGCGCTCCGGGCTGGGGCGGCCCGCGTTGTGAGACCCCTTC
  CGCAGCCCCTGAGGTCCCCGAGGAGCCACGGTGCCCGCGAGCGGCTTGCCAGGCCAAGCGAGGGGACCAG
  AACTGCGATCGTGAGTGCAACACCCCAGGCTGTGGCTGGGATGGCGGTGACTGCTCACTGAACGTGGACG
  ACCCCTGGAGGCAGTGTGAGGCACTGCAGTGCTGGCGTCTCTTCAACAACAGCCGGTGTGACCCGGCCTG
  CAGCTCTCCAGCCTGCCTCTATGACAACTTTGACTGCTACTCTGGTGGCCGCGACCGCACCTGCAACCCT
  GTTTATGAGAAGTACTGCGCCGACCACTTTGCAGATGGCCGTTGTGACCAGGGCTGCAACACTGAGGAAT
  GCGGCTGGGATGGGCTGGACTGTGCCAGCGAGGTCCCGGCCCTTTTGGCCCGAGGGGTTCTGGTCCTCAC
  AGTTCTTCTGCCTCCTGAAGAGTTGCTGCGCTCCAGTGCCGACTTTCTGCAGCGACTCAGCGCTATTCTG
  CGCACCTCACTGCGCTTCCGCTTGGACGCACGTGGCCAGGCCATGGTCTTCCCCTATCACCGGCCAAGCC
  CTGGCTCTGAATCCCGGGTCCGTCGTGAGCTGGGTCCTGAGGTGATCGGCTCTGTGGTGATGCTGGAGAT
  TGACAACCGGCTCTGTCTGCAGTCAGCTGAGAATGACCACTGCTTCCCTGATGCCCAGAGTGCTGCTGAC
  TACCTGGGAGCCTTGTCAGCAGTGGAGCGACTTGATTTCCCATACCCACTTCGGGATGTGCGAGGAGAGC
  CGCTGGAGGCCCCAGAGCAGAGCGTGCCACTGCTGCCACTGCTGGTGGCAGGGGCTGTCTTTCTACTCAT
  CATCTTCATCCTGGGTGTCATGGTTGCCAGGCGAAAGCGAGAACACAGCACCCTCTGGTTCCCTGAGGGT
  TTTGCATTACACAAGGACATAGCTGCTGGCCACAAGGGCCGGAGGGAGCCTGTGGGACAAGATGCACTGG
  GAATGAAGAACATGGCCAAGGGTGAGAGTCTGATGGGGGAGGTGGTCACAGACTTGAATGACTCAGAATG
  TCCAGAGGCCAAGAGACTGAAGGTAGAGGAGCCGGGCATGGGTGCAGAGGAGCCTGAGGACTGTCGCCAG
  TGGACCCAACACCACCTGGTTGCTGCTGATATCCGTGTGGCACCAGCCACAGCGCTGACTCCTCCTCAGG
  GAGATGCAGATGCAGACGGAGTGGATGTCAACGTCCGAGGGCCTGATGGCTTCACCCCACTTATGCTGGC
  CTCCTTCTGTGGGGGAGCCCTGGAGCCGATGCCAGCTGAGGAGGATGAGGCGGATGACACATCAGCCAGC
  ATTATCTCAGATCTGATCTGTCAAGGGGCCCAGCTCGGGGCACGGACTGACCGCACTGGCGAGACCGCCC
  TGCATTTGGCTGCCCGCTATGCTAGAGCGGATGCAGCCAAGCGTCTCCTGGATGCTGGGGCGGACACCAA
  CGCCCAGGATCATTCGGGCCGCACCCCCCTGCACACCGCAGTGACAGCTGATGCCCAGGGTGTCTTCCAG
  ATTCTCATCAGGAACCGCTCCACTGACCTGGATGCCCGAATGGCAGATGGCTCTACTGCACTGATCCTGG
  CAGCCCGCCTGGCAGTGGAGGGCATGGTGGAAGAGCTCATCGCCAGCCATGCCGATGTCAATGCAGTGGA
  TGAGCTTGGGAAATCTGCCTTACACTGGGCTGCAGCTGTGAACAACGTGGAGGCTACCTTGGCTCTGCTG
  AAAAATGGAGCCAACAAGGACATGCAGGACAGCAAGGAAGAGACGCCGCTGTTCTTGGCCGCTCGGGAGG
  GCAGCTATGAGGCTGCCAAGCTGCTGCTGGATCATCTCGCCAACCGGGAGATCACAGATCACTTGGACAG
  GCTGCCCCGGGACGTGGCCCAGGAGCGGCTGCACCAGGACATTGTGCGGTTGCTGGACCAGCCCAGTGGA
  CCTCGAAGTCCCTCTGGTCCCCATGGCTTAGGGCCATTGCTCTGCCCACCAGGGGCCTTCCTTCCTGGCC
  TCAAAGCGGTGCAGTCTGGGACCAAGAAGAGCAGGAGGCCACCTGGCAAGACCGGGCTGGGGCCACAGGG
  AACTCGTGGTCGGGGCAAGAAGCTGACACTAGCCTGTCCAGGACCTCTGGCAGACAGCTCTGTCACACTG
  TCACCGGTGGACTCTCTGGACTCACCACGGCCTTTCAGTGGGCCCCCTGCTTCCCCTGGAGGCTTCCCCT
  TGGAGGGCCCCTATGCCACCACGGCCACCGCGGTGTCCTTGGCACAGCTAGGCGCAAGTAGGGCGGGTCC
  TCTGGGGCGCCAGCCTCCTGGGGGCTGTGTGCTCAGCTTTGGTCTGCTCAATCCTGTAGCTGTTCCCCTC
  GACTGGGCCAGGCTGCCTCCACCTGCCCCTCCAGGGCCCTCATTCCTGCTGCCCCTGGCTCCGGGACCCC
  AGTTGCTCAACCCAGGAGCCCCAGTTTCTCCCCAAGAGCGGCCCCCACCCTACCTGGCTGCTCCAGGACA
  TGGAGAGGAATATCCTGCAGCAGGAACCCGCAGTAGCCCCACCAAGGCCCGCTTCCTGCGGGTTCCCAGC
  GAGCATCCTTATTTGACCCCGTCTCCTGAGTCCCCAGAGCACTGGGCCAGCCCATCCCCCCCATCCCTCT
  CAGACTGGTCTGACTCAACACCTAGCCCAGCAACTGCTACCAATGCCACAGCCTCTGGAGCCCTGCCTGC
  TCAGCCACACCCCATATCTGTTCCCTCCCTCCCTCAGTCCCAGACTCAGCTGGGACCCCAACCAGAAGTT
  ACCCCCAAGAGGCAGGTGATGGCC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >MR212149 representing NM_008716
  Red=Cloning site Green=Tags(s)
  
  MGLGARGRRRRRRLMALPPPPPPMRALPLLLLLAGLGAAAPPCLDGSPCANGGRCTHQQPSLEAACLCLP
  GWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCLRGFQGPDCSQPDPCVSRPCVHGAPCSVGPD
  GRFACACPPGYQGQSCQSDIDECRSGTTCRHGGTCLNTPGSFRCQCPLGYTGLLCENPVVPCAPSPCRNG
  GTCRQSSDVTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQ
  LQPNACHNGGTCFNLLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLC
  HLDDACVSNPCHEDAICDTNPVSGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQC
  GRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVN
  GFSCTCPSGFSGSMCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCERNVDDCSPDPCHHGRC
  VDGIASFSCACAPGYTGIRCESQVDECRSQPCRYGGKCLDLVDKYLCRCPPGTTGVNCEVNIDDCASNPC
  TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFHCLCPPGSLPPLCLPANHPC
  AHKPCSHGVCHDAPGGFRCVCEPGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIGFRCTCAPGFQGHQC
  EVLSPCTPSLCEHGGHCESDPDRLTVCSCPPGWQGPRCQQDVDECAGASPCGPHGTCTNLPGNFRCICHR
  GYTGPFCDQDIDDCDPNPCLHGGSCQDGVGSFSCSCLDGFAGPRCARDVDECLSSPCGPGTCTDHVASFT
  CACPPGYGGFHCEIDLPDCSPSSCFNGGTCVDGVSSFSCLCRPGYTGTHCQYEADPCFSRPCLHGGICNP
  THPGFECTCREGFTGSQCQNPVDWCSQAPCQNGGRCVQTGAYCICPPGWSGRLCDIQSLPCTEAAAQMGV
  RLEQLCQEGGKCIDKGRSHYCVCPEGRTGSHCEHEVDPCTAQPCQHGGTCRGYMGGYVCECPAGYAGDSC
  EDNIDECASQPCQNGGSCIDLVARYLCSCPPGTLGVLCEINEDDCDLGPSLDSGVQCLHNGTCVDLVGGF
  RCNCPPGYTGLHCEADINECRPGACHAAHTRDCLQDPGGHFRCVCHPGFTGPRCQIALSPCESQPCQHGG
  QCRHSLGRGGGLTFTCHCVPPFWGLRCERVARSCRELQCPVGIPCQQTARGPRCACPPGLSGPSCRVSRA
  SPSGATNASCASAPCLHGGSCLPVQSVPFFRCVCAPGWGGPRCETPSAAPEVPEEPRCPRAACQAKRGDQ
  NCDRECNTPGCGWDGGDCSLNVDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCYSGGRDRTCNP
  VYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAIL
  RTSLRFRLDARGQAMVFPYHRPSPGSESRVRRELGPEVIGSVVMLEIDNRLCLQSAENDHCFPDAQSAAD
  YLGALSAVERLDFPYPLRDVRGEPLEAPEQSVPLLPLLVAGAVFLLIIFILGVMVARRKREHSTLWFPEG
  FALHKDIAAGHKGRREPVGQDALGMKNMAKGESLMGEVVTDLNDSECPEAKRLKVEEPGMGAEEPEDCRQ
  WTQHHLVAADIRVAPATALTPPQGDADADGVDVNVRGPDGFTPLMLASFCGGALEPMPAEEDEADDTSAS
  IISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQ
  ILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALL
  KNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRLLDQPSG
  PRSPSGPHGLGPLLCPPGAFLPGLKAVQSGTKKSRRPPGKTGLGPQGTRGRGKKLTLACPGPLADSSVTL
  SPVDSLDSPRPFSGPPASPGGFPLEGPYATTATAVSLAQLGASRAGPLGRQPPGGCVLSFGLLNPVAVPL
  DWARLPPPAPPGPSFLLPLAPGPQLLNPGAPVSPQERPPPYLAAPGHGEEYPAAGTRSSPTKARFLRVPS
  EHPYLTPSPESPEHWASPSPPSLSDWSDSTPSPATATNATASGALPAQPHPISVPSLPQSQTQLGPQPEV
  TPKRQVMA
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_008716
• ORF Size: 6954 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_008716.3
• RefSeq Size: 7943 bp
• RefSeq ORF: 6957 bp
• Locus ID: 18131
• UniProt ID: Q61982
• Cytogenetics: 17 17.37 cM
• MW: 244.2 kDa
• Gene Summary: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development.[UniProtKB/Swiss-Prot Function]