c Kit (KIT) Mouse Monoclonal Antibody [Clone ID: 104D2]

CAT#: SM1720B

c Kit (KIT) mouse monoclonal antibody, clone 104D2, Biotin

Product Images

Surface staining of human peripheral blood cells with anti-CD117 (104D2) purified.

Specifications

Product Data

• Clone Name: 104D2
• Applications: FC
• Recommended Dilution: Indirect immunofluorescence analysis by Flow cytometry.
• Reactivities: Bovine, Human, Primate
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: MOLM-1 megakaryocytic cells
• Specificity: This antibody detects extracellular part of CD117 / c-Kit protooncogen.
• Formulation: Phosphate buffered saline (PBS)
  Label: Biotin
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 7.4
  Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: KIT proto-oncogene receptor tyrosine kinase
• Database Link:
  Entrez Gene 3815 Human
  UniProt ID P10721
• Background: CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.
• Synonyms: SCFR, KIT