CD283 / TLR3 (LRR20) Mouse Monoclonal Antibody [Clone ID: 1210F1 / TLR3.2]

CAT#: DDX0477A546-100

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CD283 / TLR3 (LRR20) mouse monoclonal antibody, clone 1210F1 / TLR3.2

Product Datasheet for 'DDX0477A546-100'

USD 530.00

2 Weeks

    • 100 ug

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Product Data
Clone Name 1210F1 / TLR3.2
Applications FC, IF, IP, WB
Recommended Dilution FACS intracellular, ImmunoFluorescence, Immunoprecipitation, Western Blot. 

Usage recommendation:

*This monoclonal antibody may be used between 5-20 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before using.
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen HEK-293 stably transfected with huTLR3+rhu TLR3 ECD (R&D)
Specificity Human TLR3. 
Recognizez Mouse TLR3 (WB).
Formulation Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol.
Label: Alexa Fluor 546
Concentration 0.5 mg/ml
Purification QMA Hyper D ion exchange chromatography
Conjugation Alexa Fluor 546
Background The Toll-like receptor (TLR) family are considered as key for sensing microbial infections and triggering inflammatory and innate responses. 3 novel mAbs were generated against TLR3 that support the emergence of an alternative model for TLR3 biology: TLR3 full-length (TLR3FL, 130KDa) corresponds to the TLR3 present in ER, which in resting cells is steadily converted within the Golgi into fully glycosylated TLR3 (TLR3FL+, 135KDa) and then rapidly cleaved by cathepsins in the endosome/lysosome into 2 long-lived associated fragments (72 KDa and 60KDa). (Toscano F et al, J. Immunol, 2013, 190: 764–773).
Synonyms Toll-like receptor 3
Reference Data
Customer Reviews 
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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