Tnni3 pSer150 Rabbit Polyclonal Antibody
Other products for "Tnni3"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western blot: 1/1000. Immunolabeling is greatly decreased with lambda -phosphatase treatment. |
Reactivities | Human, Mouse, Primate, Rat |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser 150 of Mouse Troponin I, cardiac (cTnI). |
Specificity | Specific for the ~25k cardiac troponin I protein phosphorylated at Ser 150. |
Formulation | 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50% glycerol State: Aff - Purified State: Liquid purified Ig fraction |
Purification | Affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns |
Conjugation | Unconjugated |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | troponin I, cardiac 3 |
Database Link | |
Background | Troponin I (TnI) is 1 of 3 subunits, along with troponin C (TnC) and Troponin T (TnT) of troponin complex found in cardiac (cTnI) and fast skeletal (fsTnI) muscle. cTnI is phosphorylated by protein kinase C and protein kinase A at Ser 23/24 (Noland et al, 1995) and is phosphorylated by AMPK at Ser 23 and Ser 150 (Solis et al, 2011). Evidence su ggests that AMPK, a critical regulator of cardiac energetics, prefers phosphorylating Ser 150 over Ser 23 , and may play a role in regulating energy consumption through altering the p hosphorylation status of cTnI (Solis et al., 2011). |
Synonyms | TNNI3, TNNC1 |
Reference Data |
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