PTCH1 (C-term) Goat Polyclonal Antibody

CAT#: AP22448PU-N

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PTCH1 (C-term) goat polyclonal antibody, Aff - Purified


Product Datasheet for 'AP22448PU-N'


 Cited in 2 publications.

USD 375.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Applications ELISA, IF, IHC
Recommend Dilution Peptide ELISA: 1/8000 (Detection Limit). 
Immunohsitochemistry on Paraffin Sections: 3-6 µg/ml.
Staining of Embedded Human Colon shows textured nuclear staining of the absorptive cells.
Immunofluorescence: 5 µg/ml. Expression of the protein seen in the cytoplasm of HeLa and in the Golgi/membrane of NIH3T3 cells.
Reactivity Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence from the C Terminus of Human PTCH1 (NP_001077073.1, NP_001077074.1, NP_001077075.1, NP_001077076.1)
Specificity This antibody is expected to recognise all reported isoforms of PTCH1. 
Variants (NP_001077073.1; NP_001077074.1; NP_001077075.1; NP_001077076.1) encode the same isoform.
Formulation Tris saline, pH~7.3
State: Aff - Purified
State: Liquid purified Ig fraction
Stabilizer: 0.5% BSA
Preservative: 0.02% Sodium Azide
Concentration 0.5 mg/ml
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Gene Name Homo sapiens patched 1 (PTCH1), transcript variant 1b
Background PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud.
Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome.
Synonyms PTCH, PTC1, PTC, Patched 1
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Citations (2)

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