S100A10 Rabbit Polyclonal Antibody
S100A10 rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Western blot: 1/500 - 1/1000.
Immunohistochemistry on paraffin sections: 1/50 - 1/200.
|Reactivity||Human, Mouse, Rat|
|Specificity||This antibody detects endogenous levels of S-100A10 protein.
(region surrounding Val52)
|Formulation||PBS, pH 7.2
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% sodium azide
|Purification||Affinity chromatography (> 95% (by SDS-PAGE)|
|Storage||Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||~ 11 kDa|
|Gene Name||Homo sapiens S100 calcium binding protein A10 (S100A10)|
|Background||The S-100 family of calcium-activated proteins interact with a range of target proteins to modulate biological signaling pathways. Numerous cancer cell lines overexpress the plasminogen receptor S-100A10 on the extracellular cell surface, where it forms a heterotetrameric complex with Annexin II, though this association is not required for plasma membrane localization or binding and activation of plasminogen. Additionally, S-100A10 acts as a cellular chaperone for hepatitis B (Hep B) virus polymerase. Hep B virus polymerase normally localizes to the cytoplasm only, though in the presence of S-100A10 a portion relocates to the nucleus, implying a role for S-100A10 and intracellular calcium in the process of viral replication.|
|Synonyms||S100-A10, ANX2LG, CAL1L, CLP11, Calpactin-1 light chain|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.