AMPK alpha 2 (PRKAA2) Rabbit Polyclonal Antibody

CAT#: AP13880PU-N

Rabbit Polyclonal Anti-PRKAA2 Antibody, Purified


 Product Datasheet for 'AP13880PU-N'

USD 415.00


Availability*
2 Weeks

Size
    • 0.4 ml


Product images

Specifications

Product Data
Applications WB
Recommend Dilution WB
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human AMPK.
Isotype IgG
Formulation PBS with 0.09% (W/V) sodium azide
Concentration lot specific
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Predicted Protein Size 62.1 kDa
Gene Name protein kinase AMP-activated catalytic subunit alpha 2
Background AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Synonyms AMPK; AMPK2; AMPKa2; PRKAA
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway, mTOR signaling pathway, Regulation of autophagy
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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68 Mouse Clones