AMPK alpha 2 (PRKAA2) Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-PRKAA2 Antibody, Purified
Product Datasheet for 'AP13880PU-N'
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human AMPK.|
|Formulation||PBS with 0.09% (W/V) sodium azide|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Predicted Protein Size||62.1 kDa|
|Gene Name||protein kinase AMP-activated catalytic subunit alpha 2|
|Background||AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.|
|Synonyms||AMPK; AMPK2; AMPKa2; PRKAA|
|Protein Families||Druggable Genome, Protein Kinase|
|Protein Pathways||Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway, mTOR signaling pathway, Regulation of autophagy|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.