AMPK alpha 2 (PRKAA2) (C-term) Rabbit Polyclonal Antibody
Other products for "PRKAA2"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA 1:1,000. Western blot 1:100 - 1:500. Flow cytometry. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human AMPK. |
Specificity | This antibody detects AMPK alpha2 at C-term. |
Formulation | PBS with 0.09% (W/V) sodium azide State: Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Conjugation | Unconjugated |
Storage | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | protein kinase AMP-activated catalytic subunit alpha 2 |
Database Link | |
Background | AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |
Synonyms | AMPK2, AMPK alpha-2 chain |
Note | Molecular weight: 62319 Da. |
Reference Data |
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