RANKL (TNFSF11) (287-304) Rabbit Polyclonal Antibody
RANKL (TNFSF11) (287-304) rabbit polyclonal antibody, Serum
|Immunogen||Human sRANKL synthetic Peptide (EEISIEVSNPSLLDPDQD)|
|Specificity||Recognizes Human sRANKL (soluble form). Other species not tested.|
State: Lyophilized Serum.
|Reconstitution Method||Restore in aqua bidest to initial volume.|
|Gene Name||Homo sapiens tumor necrosis factor superfamily member 11 (TNFSF11), transcript variant 1|
|Background||RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. There are three isoforms of RANKL. Human RANKL is a soluble 20 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues). This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor associated factor (TRAF) 6, which indicated that this protein may have a role in the regulation of cell apoptosis. RANKL deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.|
|Synonyms||OPGL, RANK Ligand, RANKL, TRANCE, TNFSF11, ODF|
|Protein Families||Druggable Genome, Transmembrane|
|Protein Pathways||Cytokine-cytokine receptor interaction|
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