Gremlin 1 (GREM1) (NM_013372) Human Recombinant Protein

CAT#: TP723147

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Purified recombinant protein of Human gremlin 1 (GREM1), transcript variant 1.


Product Datasheet for 'TP723147'


 Cited in 1 publication.

  View other "GREM1" proteins (3)

USD 240.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Description Purified recombinant protein of Human gremlin 1 (GREM1), transcript variant 1.
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence KKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
Tag Tag Free
Predicted MW 18.3 kDa
Concentration Resuspend the protein in the desired concentration in proper buffer
Purity >90% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
Bioactivity Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11ug/mL.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Storage Store at -80°C.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_037504
Locus ID 26585
Refseq Size 4150
Cytogenetics 15q13.3
Refseq ORF 552
Synonyms C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
Summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Protein Families ES Cell Differentiation/IPS, Secreted Protein

Citations (1)

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