Tnfrsf1a Mouse Gene Knockout Kit (CRISPR)

CAT#: KN317983

Tnfrsf1a - mouse gene knockout kit via CRISPR

change donor?

USD 1,290


Availability*
4 Weeks

Size
    • 1 kit

Product images

Specifications

Product Data
Symbol Tnfrsf1a
Locus ID 21937
Kit Components

KN317983G1, Tnfrsf1a gRNA vector 1 in pCas-Guide vector,

KN317983G2, Tnfrsf1a gRNA vector 2 in pCas-Guide vector,

KN317983-D, donor vector containing Left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq BC004599, BC052675, NM_011609
Synonyms CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
Summary This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents