PGPEP1 Human Gene Knockout Kit (CRISPR)

CAT#: KN214837

PGPEP1 - human gene knockout kit via CRISPR

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USD 1,290.00


Availability*
4 Weeks

Size
    • 1 kit

Product images

Specifications

Product Data
Symbol PGPEP1
Locus ID 54858
Kit Components

KN214837G1, PGPEP1 gRNA vector 1 in pCas-Guide vector,

KN214837G2, PGPEP1 gRNA vector 2 in pCas-Guide vector,

KN214837-D, donor vector containing Left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq BC042138, NM_001300927, NM_001308366, NM_001329471, NM_001329476, NM_001329477, NM_001329478, NM_017712, NR_138029, XM_006722783, XM_011528112
Synonyms PAP-I; Pcp; PGI; PGP; PGP-I; PGPI
Summary The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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