PGPEP1 Human Gene Knockout Kit (CRISPR)
PGPEP1 - human gene knockout kit via CRISPRchange donor?
KN214837G1, PGPEP1 gRNA vector 1 in pCas-Guide vector,
KN214837G2, PGPEP1 gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||BC042138, NM_001300927, NM_001308366, NM_001329471, NM_001329476, NM_001329477, NM_001329478, NM_017712, NR_138029, XM_006722783, XM_011528112|
|Synonyms||PAP-I; Pcp; PGI; PGP; PGP-I; PGPI|
|Summary||The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016].|
|Gene Expression Resources|
"PGPEP1" in other Product Lines
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