PRKCH Human Gene Knockout Kit (CRISPR)
PRKCH - human gene knockout kit via CRISPRchange donor?
KN205272G1, PRKCH gRNA vector 1 in pCas-Guide vector,
KN205272G2, PRKCH gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_006255, NM_024064, XM_011536954, XM_011536955, XM_011536956, XM_011536957, XM_017021458, XM_017021459|
|Synonyms||nPKC-eta; PKC-L; PKCL; PRKCL|
|Summary||Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015].|
|Gene Expression Resources|
"PRKCH" in other Product Lines
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