SUCLA2 Human Gene Knockout Kit (CRISPR)
SUCLA2 - human gene knockout kit via CRISPRchange donor?
KN205212G1, SUCLA2 gRNA vector 1 in pCas-Guide vector,
KN205212G2, SUCLA2 gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_003850, XM_017020806, XM_017020807, XM_017020808, XM_017020809, XR_001749704|
|Synonyms||A-BETA; MTDPS5; SCS-betaA|
|Summary||Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]|
|Gene Expression Resources|
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