SDC2 Human Gene Knockout Kit (CRISPR)
SDC2 - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN203366G1, SDC2 gRNA vector 1 in pCas-Guide vector
KN203366G2, SDC2 gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_002998, XM_011517212, XM_040582|
|Synonyms||CD362; HSPG; HSPG1; SYND2|
|Summary||The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]|
|Gene Expression Resources|