CDC42EP4 Human Gene Knockout Kit (CRISPR)
CDC42EP4 - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN201162G1, CDC42EP4 gRNA vector 1 in pCas-Guide vector
KN201162G2, CDC42EP4 gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|Synonyms||BORG4; CEP4; KAIA1777|
|Summary||The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008].|
|Gene Expression Resources|