Mouse C5ar1 activation kit by CRISPRa

CAT#: GA200470

C5ar1 CRISPRa kit - CRISPR gene activation of mouse complement component 5a receptor 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: C5ar1
• Locus ID: 12273
• Kit Components:

  GA200470G1, C5ar1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200470G2, C5ar1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200470G3, C5ar1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001173550, NM_007577
• UniProt ID: P30993
• Synonyms: C5aR; C5r1; Cd88; D7Msu1
• Summary: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.[UniProtKB/Swiss-Prot Function]