Human Leucyl tRNA synthetase (LARS) activation kit by CRISPRa

CAT#: GA109848

LARS CRISPRa kit - CRISPR gene activation of human leucyl-tRNA synthetase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: LARS1
• Locus ID: 51520
• Kit Components:

  GA109848G1, Leucyl tRNA synthetase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109848G2, Leucyl tRNA synthetase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109848G3, Leucyl tRNA synthetase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317964, NM_001317965, NM_016460, NM_020117
• UniProt ID: Q9P2J5
• Synonyms: hr025Cl; HSPC192; ILFS1; LARS1; LEURS; LEUS; LFIS; LRS; PIG44; RNTLS
• Summary: This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]