Human ERCC8 activation kit by CRISPRa

CAT#: GA100833

ERCC8 CRISPRa kit - CRISPR gene activation of human ERCC excision repair 8, CSA ubiquitin ligase complex subunit

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ERCC8
• Locus ID: 1161
• Kit Components:

  GA100833G1, ERCC8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100833G2, ERCC8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100833G3, ERCC8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000082, NM_001007233, NM_001007234, NM_001290285
• UniProt ID: Q13216
• Synonyms: CKN1; CSA; UVSS2
• Summary: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]