RUNX1 (NM_001754) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC223809L4V

Lenti ORF particles, RUNX1 (mGFP-tagged) - Human runt-related transcription factor 1 (RUNX1), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC223809L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC223809L4V particle to overexpress human RUNX1-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: RUNX1
• Synonyms: AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2; EVI-1; PEBP2aB; PEBP2alpha
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_001754
• ORF Size: 1440 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC223809).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001754.3
• RefSeq Size: 6190 bp
• RefSeq ORF: 1443 bp
• Locus ID: 861
• UniProt ID: Q01196
• Cytogenetics: 21q22.12
• Domains: Runt
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Chronic myeloid leukemia, Pathways in cancer
• MW: 51.6 kDa
• Gene Summary: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]