MYLK3 (NM_182493) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC222246L2V

Lenti ORF particles, MYLK3 (mGFP-tagged)-Human myosin light chain kinase 3 (MYLK3), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: MYLK3
• Synonyms: caMLCK; MLCK; MLCK2
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_182493
• ORF Size: 2457 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC222246).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_182493.2
• RefSeq Size: 7998 bp
• RefSeq ORF: 2460 bp
• Locus ID: 91807
• UniProt ID: Q32MK0
• Cytogenetics: 16q11.2
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Calcium signaling pathway, Focal adhesion, Regulation of actin cytoskeleton, Vascular smooth muscle contraction
• MW: 88.8 kDa
• Gene Summary: Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]