DR5 (TNFRSF10B) (NM_003842) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC201588L3V

Lenti ORF particles, TNFRSF10B (Myc-DDK tagged) - Human tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC201588L3 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC201588L3V particle to overexpress human TNFRSF10B-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: DR5
• Synonyms: CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_003842
• ORF Size: 1320 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC201588).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003842.3, NP_003833.3
• RefSeq Size: 4154 bp
• RefSeq ORF: 1323 bp
• Locus ID: 8795
• UniProt ID: O14763
• Cytogenetics: 8p21.3
• Domains: DEATH, TNFR
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity, p53 signaling pathway
• MW: 47.9 kDa
• Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]