DR5 (TNFRSF10B) (NM_003842) Human Untagged Clone

CAT#: SC111085

TNFRSF10B (untagged)-Human tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DR5
• Synonyms: CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003842 edited
  GCGCTTGCGGAGGATTGCGTTGACGAGACTCTTATTTATTGTCACCAACCTGTGGTGGAA
  TTTGCAGTTGCACATTGGATCTGATTCGCCCCGCCCCGAATGACGCCTGCCCGGAGGCAG
  TGAAAGTACAGCCGCGCCGCCCCAAGTCAGCCTGGACACATAAATCAGCACGCGGCCGGA
  GAACCCCGCAATCTCTGCGCCCACAAAATACACCGACGATGCCCGATCTACTTTAAGGGC
  TGAAACCCACGGGCCTGAGAGACTATAAGAGCGTTCCCTACCGCCATGGAACAACGGGGA
  CAGAACGCCCCGGCCGCTTCGGGGGCCCGGAAAAGGCACGGCCCAGGACCCAGGGAGGCG
  CGGGGAGCCAGGCCTGGGCTCCGGGTCCCCAAGACCCTTGTGCTCGTTGTCGCCGCGGTC
  CTGCTGTTGGTCTCAGCTGAGTCTGCTCTGATCACCCAACAAGACCTAGCTCCCCAGCAG
  AGAGCGGCCCCACAACAAAAGAGGTCCAGCCCCTCAGAGGGATTGTGTCCACCTGGACAC
  CATATCTCAGAAGACGGTAGAGATTGCATCTCCTGCAAATATGGACAGGACTATAGCACT
  CACTGGAATGACCTCCTTTTCTGCTTGCGCTGCACCAGGTGTGATTCAGGTGAAGTGGAG
  CTAAGTCCCTGCACCACGACCAGAAACACAGTGTGTCAGTGCGAAGAAGGCACCTTCCGG
  GAAGAAGATTCTCCTGAGATGTGCCGGAAGTGCCGCACAGGGTGTCCCAGAGGGATGGTC
  AAGGTCGGTGATTGTACACCCTGGAGTGACATCGAATGTGTCCACAAAGAATCAGGTACA
  AAGCACAGTGGGGAAGCCCCAGCTGTGGAGGAGACGGTGACCTCCAGCCCAGGGACTCCT
  GCCTCTCCCTGTTCTCTCTCAGGCATCATCATAGGAGTCACAGTTGCAGCCGTAGTCTTG
  ATTGTGGCTGTGTTTGTTTGCAAGTCTTTACTGTGGAAGAAAGTCCTTCCTTACCTGAAA
  GGCATCTGCTCAGGTGGTGGTGGGGACCCTGAGCGTGTGGACAGAAGCTCACAACGACCT
  GGGGCTGAGGACAATGTCCTCAATGAGATCGTGAGTATCTTGCAGCCCACCCAGGTCCCT
  GAGCAGGAAATGGAAGTCCAGGAGCCAGCAGAGCCAACAGGTGTCAACATGTTGTCCCCC
  GGGGAGTCAGAGCATCTGCTGGAACCGGCAGAAGCTGAAAGGTCTCAGAGGAGGAGGCTG
  CTGGTTCCAGCAAATGAAGGTGATCCCACTGAGACTCTGAGACAGTGCTTCGATGACTTT
  GCAGACTTGGTGCCCTTTGACTCCTGGGAGCCGCTCATGAGGAAGTTGGGCCTCATGGAC
  AATGAGATAAAGGTGGCTAAAGCTGAGGCAGCGGGCCACAGGGACACCTTGTACACGATG
  CTGATAAAGTGGGTCAACAAAACCGGGCGAGATGCCTCTGTCCACACCCTGCTGGATGCC
  TTGGAGACGCTGGGAGAGAGACTTGCCAAGCAGAAGATTGAGGACCACTTGTTGAGCTCT
  GGAAAGTTCATGTATCTAGAAGGTAATGCAGACTCTGCCATGTCCTAAGTGTGATTCTCT
  TCAGGAAGTCAGACCTTCCCTGGTTTACCTTTTTTCTGGAAAAAGCCCAACTGGACTCCA
  GTCAGTAGGAAAGTGCCACAATTGTCACATGACCGGTACTGGAAGAAACTCTCCCATCCA
  ACATCACCCAGTGGATGGAACATCCTGTAACTTTTCACTGCACTTGGCATTATTTTTATA
  AGCTGAATGTGATAATAAGGACACTATGGAAATGTCTGGATCATTCCGTTTGTGCGTACT
  TTGAGATTTGGTTTGGGATGTCATTGTTTTCACAGCACTTTTTTATCCTAATGTAAATGC
  TTTATTTATTTATTTGGGCTACATTGTAAGATCCATCTACACAGTCGTTGTCCGACTTCA
  CTTGATACTATATGATATGAACCTTTTTTGGGTGGGGGGTGCGGGGCAGTTCACTCTGTC
  TCCCAGGCTGGAGTGCAATGGTGCAATCTTGGCTCACTATAGCCTTGACCTCTCAGGCTC
  AAGCGATTCTCCCACCTCAGCCATCCAAATAGCTGGGACCACAGGTGTGCACCACCACGC
  CCGGCTAATTTTTTGTATTTTGTCTAGATATAGGGGCTCTCTATGTTGCTCAGGGTGGTC
  TCGAATTCCTGGACTCAAGCAGTCTGCCCACCTCAGACTCCCAAAGCGGTGGAATTAGAG
  GCGTGAGCCCCCATGCTTGGCCTTACCTTTCTACTTTTATAATTCTGTATGTTATTATTT
  TATGAACATGAAGAAACTTTAGTAAATGTACTTGTTTACATAGTTATGTGAATAGATTAG
  ATAAACATAAAAGGAGGAGACATACAATGGGGGAAGAAGAAGAAGTCCCCTGTAAGATGT
  CACTGTCTGGGTTCCAGCCCTCCCTCAGATGTACTTTGGCTTCAATGATTGGCAACTTCT
  ACAGGGGCCAGTCTTTTGAACTGGACAACCTTACAAGTATATGAGTATTATTTATAGGTA
  GTTGTTTACATATGAGTCGGGACCAAAGAGAACTGGATCCACGTGAAGTCCTGTGTGTGG
  CTGGTCCCTACCTGGGCAGTCTCATTTGCACCCATAGCCCCCATCTATGGACAGGCTGGG
  ACAGAGGCAGATGGGTTAGATCACACATAACAATAGGGTCTATGTCATATCCCAAGTGAA
  CTTGAGCCCTGTTTGGGCTCAGGAGATAGAAGACAAAATCTGTCTCCCACGTCTGCCATG
  GCATCAAGGGGGAAGAGTAGATGGTGCTTGAGAATGGTGTGAAATGGTTGCCATCTCAGG
  AGTAGATGGCCCGGCTCACTTCTGGTTATCTGTCACCCTGAGCCCATGAGCTGCCTTTTA
  GGGTACAGATTGCCTACTTGAGGACCTTGGCCGCTCTGTAAGCATCTGACTCATCTCAGA
  AATGTCAATTCTTAAACACTGTGGCAACAGGACCTAGAATGGCTGACGCATTAAGGTTTT
  CTTCTTGTGTCCTGTTCTATTATTGTTTTAAGACCTCAGTAACCATTTCAGCCTCTTTCC
  AGCAAACCCTTCTCCATAGTATTTCAGTCATGGAAGGATCATTTATGCAGGTAGTCATTC
  CAGGAGTTTTTGGTCTTTTCTGTCTCAAGGCATTGTGTGTTTTGTTCCGGGACTGGTTTG
  GGTGGGACAAAGTTAGAATTGCCTGAAGATCACACATTCAGACTGTTGTGTCTGTGGAGT
  TTTAGGAGTGGGGGGTGACCTTTCTGGTCTTTGCACTTCCATCCTCTCCCACTTCCATCT
  GGCATCCCACGCGTTGTCCCCTGCACTTCTGGAAGGCACAGGGTGCTGCTGCCTCCTGGT
  CTTTGCCTTTGCTGGGCCTTCTGTGCAGGACGCTCAGCCTCAGGGCTCAGAAGGTGCCAG
  TCCGGTCCCAGGTCCCTTGTCCCTTCCACAGAGGCCTTCCTAGAAGATGCATCTAGAGTG
  TCAGCCTTATCAGTGTTTAAGATTTTTCTTTTATTTTTAATTTTTTTGAGACAGAATCTC
  ACTCTCTCGCCCAGGCTGGAGTGCAACGGTACGATCTTGGCTCAGTGCAACCTCCGCCTC
  CTGGGTTCAAGCGATTCTCGTGCCTCAGCCTCCGGAGTAGCTGGGATTGCAGGCACCCGC
  CACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAG
  GCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTTGGCCTCCGAAAGTGCTGGGATTA
  CAGGCGTGAGCCACCAGCCAGGCCAAGCTATTCTTTTAAAGTAAGCTTCCTGACGACATG
  AAATAATTGGGGGTTTTGTTGTTTAGTTACATTAGGCTTTGCTATATCCCCAGGCCAAAT
  AGCATGTGACACAGGACAGCCATAGTATAGTGTGTCACTCGTGGTTGGTGTCCTTTCATG
  CTTCTGCCCTGTCAAAGGTCCCTATTTGAAATGTGTTATAATACAAACAAGGAAGCACAT
  TGTGTACAAAATACTTATGTATTTATGAATCCATGACCAAATTAAATATGAAACCTTATA
  TAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003842 unedited
  CCCCGCCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGA
  GCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAAT
  TCGGCACGAGGCATAAATCAGCACGCGGCCGGAGAACCCCGCAATCTCTGCGCCCACAAA
  ATACACCGACGATGCCCGATCTACTTTAAGGGCTGAAACCCACGGGCCTGAGAGACTATA
  AGAGCGTTCCCTACCGCCATGGAACAACGGGGACAGAACGCCCCGGCCGCTTCGGGGGCC
  CGGAAAAGGCACGGCCCAGGACCCAGGGAGGCGCGGGGAGCCAGGCCTGGGCTCCGGGTC
  CCCAAGACCCTTGTGCTCGTTGTCGCCGCGGTCCTGCTGTTGGTCTCAGCTGAGTCTGCT
  CTGATCACCCAACAAGACCTAGCTCCCCAGCAGAGAGCGGCCCCACAACAAAAGAGGTCC
  AGCCCCTCAGAGGGATTGTGTCCACCTGGACACCATATCTCAGAAGACGGTAGAGATTGC
  ATCTCCTGCAAATATGGACAGGACTATAGCACTCACTGGAATGACCTCCTTTTCTGCTTG
  CGCTGCACCAGGTGTGATTCAGGTGAAGTGGAGCTAAGTCCCTGCACCACGACCAGAAAC
  ACAGTGTGTCAGTGCGAAGAAGGCACCTTCCGGGAAGAAAGATCTCCTGAGATGTGCCGG
  AAGTGCCGCACAGGGTGTCCCAGAGGGATGGTCAGGGGTCGTGATGTACACCCTGGAGTG
  CATCGAATGTGTCCACAAGAATCAGGTACCGCACAGTGGNGAGCCCCGCTGTGGAGAGAC
  GGTGACTNCAGCCCAGGACTCTGCCTCTCCTGTTCCTCTCAGCATATCATAGAGTACAGT
  GCAGCCGANCTGATGTGGCTGGGTTGTTGCAGTCTTATGTGGGAGAAGTCTTCTA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003842 unedited
  NGGTCCTGACTNTGNNACCGCGGCCGCATNCTANGATCGAGTTTTTTTTTTTTTTTTTTA
  TATAAGGTTTCATATTTAATTTGGTCATGGATTCATAAATACATAAGTATTTTGTACACA
  ATGTGCTTCCTTGTTTGTATTATAACACATTTCAAATAGGGACCTTTGACAGGGCAGAAG
  CATGAAAGGACACCAACCACGAGTGACACACTATACTATGGCTGTCCTGTGTCACATGCT
  ATTTGGCCTGGGGATATAGCAAAGCCTAATGTAACTAAACAACAAAACCCCCAATTATTT
  CATGTCGTCAGGAAGCTTACTTTAAAAGAATAGCTTGGCCTGGCTGGTGGCTCACGCCTG
  TAATCCCAGCACTTTCGGAGGCCAAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGC
  CTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTG
  GCGGGTGCCTGCAATCCCAGCTACTCCGGAGGCTGAGGCACGAGAATCGCTTGAACCCAG
  GAGGCGGAGGTTGCACTGAGCCAAGATCGTACCGTTGCACTCCAGCCTGGGCGAGAGAGT
  GAGATTCTGTCTCAAAAAAATTAAAAATAAAAGAAAAATCTTAAACACTGATAAGGCTGA
  CACTCTAGATGCATCTTCTAGGAAGGCCTCTGTGGAAGGGACAAGGGACCTGGGACCGGA
  CTGGCACCTTCTGAGCCCTGAGGCTGAGCGTCCTGCACAGAAGGCCCAGCAAAGGCANAG
  ACCAGNAGGCAGCAGCACCCTGTGCCTTCCAGAGTGCAGGGGACAACGCGTGGGATGCCA
  NATGGAANNTGGAGAGGATGGAAGTGCAAAGACCANNAAAGGTCACCCCNCACTTCTAAA
  ACTNCACAGAACACACAGTCTGAAATGTGTGATCTTCAGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003842
• Insert Size: 4000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003842.3, NP_003833.3
• RefSeq Size: 4160 bp
• RefSeq ORF: 1323 bp
• Locus ID: 8795
• UniProt ID: O14763
• Cytogenetics: 8p21.3
• Domains: DEATH, TNFR
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity, p53 signaling pathway
• Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.