Fan1 (NM_177893) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR226479L4V
- LentiORF®
Lenti ORF particles, Fan1 (GFP-tagged) - Mouse FANCD2/FANCI-associated nuclease 1 (Fan1), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro
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USD 365.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | mGFP |
Symbol | Fan1 |
Synonyms | 6030441H18Rik; mFAN1; Mtmr15 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_177893 |
ORF Size | 3060 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR226479).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_177893.3 |
RefSeq Size | 3475 bp |
RefSeq ORF | 3063 bp |
Locus ID | 330554 |
UniProt ID | Q69ZT1 |
Cytogenetics | 7 C |
Gene Summary | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (PubMed:24981866). Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (By similarity). Also has endonuclease activity toward 5'-flaps (PubMed:24981866).[UniProtKB/Swiss-Prot Function] |
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