Nek1 (NM_175089) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR216282L4V

Lenti ORF particles, Nek1 (GFP-tagged) - Mouse NIMA (never in mitosis gene a)-related expressed kinase 1 (Nek1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Nek1
• Synonyms: D8Ertd790e; kat
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_175089
• ORF Size: 3609 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR216282).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_175089.3, NP_780298.2
• RefSeq Size: 4264 bp
• RefSeq ORF: 3612 bp
• Locus ID: 18004
• UniProt ID: P51954
• Cytogenetics: 8 30.91 cM
• Gene Summary: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:1382974). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:18843199). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (By similarity). May be implicated in the control of meiosis (PubMed:1382974). Involved in cilium assembly (By similarity).[UniProtKB/Swiss-Prot Function]