Gapvd1 (NM_025709) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR211988L3V
- LentiORF®
Lenti ORF particles, Gapvd1 (Myc-DDK-tagged) - Mouse GTPase activating protein and VPS9 domains 1 (Gapvd1), 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
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USD 365.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | Gapvd1 |
Synonyms | 2010005B09Rik; 4432404J10Rik; AW108497; Gapex-5; mKIAA1521; RAP6; RME-6 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_025709 |
ORF Size | 4311 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR211988).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_025709.2 |
RefSeq Size | 5966 bp |
RefSeq ORF | 4314 bp |
Locus ID | 66691 |
UniProt ID | Q6PAR5 |
Cytogenetics | 2 B |
Gene Summary | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.[UniProtKB/Swiss-Prot Function] |
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