Epas1 (NM_010137) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR211029L4V
- LentiORF®
Lenti ORF particles, Epas1 (GFP-tagged) - Mouse endothelial PAS domain protein 1 (Epas1), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro
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USD 365.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | mGFP |
Symbol | Epas1 |
Synonyms | bHLHe73; HIF-2alpha; HIF2A; HLF; HRF; MOP2 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_010137 |
ORF Size | 2622 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR211029).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_010137.3, NP_034267.3 |
RefSeq Size | 5352 bp |
RefSeq ORF | 2625 bp |
Locus ID | 13819 |
UniProt ID | P97481 |
Cytogenetics | 17 E4 |
Gene Summary | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).[UniProtKB/Swiss-Prot Function] |
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