NUMBL (NM_004756) Human Untagged Clone

CAT#: SC314186

NUMBL (untagged)-Human numb homolog (Drosophila)-like (NUMBL)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NUMBL
• Synonyms: CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_004756 edited
  ATGTCCCGCAGCGCGGCGGCCAGCGGCGGACCCCGGAGGCCTGAGCGGCACCTGCCCCCA
  GCCCCCTGTGGGGCCCCGGGGCCCCCAGAAACCTGCAGGACGGAGCCAGACGGGGCGGGC
  ACCATGAACAAGTTACGGCAGAGCCTGCGGCGGAGGAAGCCAGCCTACGTGCCCGAGGCG
  TCGCGCCCGCACCAGTGGCAGGCAGACGAGGACGCGGTGCGGAAGGGCACGTGCAGCTTC
  CCGGTCAGGTACCTGGGTCACGTGGAGGTAGAGGAGTCCCGGGGAATGCACGTGTGTGAA
  GATGCGGTGAAGAAGCTGAAGGCGATGGGCCGAAAGTCCGTGAAGTCTGTCCTGTGGGTG
  TCAGCCGATGGGCTCCGAGTGGTGGACGACAAAACCAAGGATCTTCTGGTCGACCAGACC
  ATCGAAAAGGTCTCCTTTTGTGCTCCTGACCGCAACCTGGACAAGGCTTTCTCCTATATC
  TGTCGTGACGGGACTACCCGCCGCTGGATCTGCCACTGTTTTCTGGCACTGAAGGACTCC
  GGCGAGAGGCTGAGCCACGCTGTGGGCTGTGCTTTTGCCGCCTGCCTGGAGCGAAAACAG
  CGACGGGAGAAGGAATGTGGGGTCACGGCCGCCTTCGATGCCAGCCGCACCAGCTTCGCC
  CGCGAGGGCTCCTTCCGCCTGTCTGGGGGTGGGCGGCCTGCTGAGCGAGAGGCCCCGGAC
  AAGAAGAAAGCAGAGGCAGCAGCTGCCCCCACTGTGGCTCCTGGCCCTGCCCAGCCTGGG
  CACGTGTCCCCGACACCAGCCACCACATCCCCTGGTGAGAAGGGTGAGGCAGGCACCCCT
  GTGGCTGCAGGCACCACTGCGGCCGCCATCCCCCGGCGCCATGCACCCCTGGAGCAGCTG
  GTTCGCCAGGGCTCCTTCCGTGGGTTCCCAGCACTCAGCCAGAAGAACTCGCCTTTCAAA
  CGGCAGCTGAGCCTACGGCTGAATGAGCTGCCATCCACGCTGCAGCGCCGCACTGACTTC
  CAGGTGAAGGGCACAGTGCCTGAGATGGAGCCTCCTGGTGCCGGCGACAGTGACAGCATC
  AACGCTCTGTGCACACAGATCAGTTCATCTTTTGCCAGTGCTGGAGCGCCAGCACCAGGG
  CCACCACCTGCCACAACAGGGACTTCTGCCTGGGGTGAGCCCTCCGTGCCCCCTGCAGCT
  GCCTTCCAGCCTGGGCACAAGCGGACACCTTCAGAGGCTGAGCGATGGCTGGAGGAGGTG
  TCACAGGTGGCCAAGGCCCAGCAGCAGCAGCAGCAACAGCAACAGCAGCAGCAGCAGCAG
  CAGCAACAGCAGCAAGCAGCCTCAGTGGCCCCAGTGCCCACCATGCCTCCTGCCCTGCAG
  CCTTTCCCCGCCCCCGTGGGGCCCTTTGACGCTGCACCTGCCCAAGTGGCCGTGTTCCTG
  CCACCCCCACACATGCAGCCCCCTTTTGTGCCCGCCTACCCGGGCTTGGGCTACCCACCG
  ATGCCCCGGGTGCCCGTGGTGGGCATCACACCCTCACAGATGGTGGCAAACGCCTTCTGC
  TCAGCCGCCCAGCTCCAGCCTCAGCCTGCCACTCTGCTTGGGAAAGCTGGGGCCTTCCCG
  CCCCCTGCCATACCCAGTGCCCCTGGGAGCCAGGCCCGCCCTCGCCCCAATGGGGCCCCC
  TGGCCCCCTGAGCCAGCGCCTGCCCCAGCTCCAGAGTTGGACCCCTTTGAGGCCCAGTGG
  GCGGCATTAGAAGGCAAAGCCACTGTAGAGAAACCCTCCAACCCCTTTTCTGGCGACCTG
  CAAAAGACATTCGAGATTGAACTGTAG
  
• Restriction Sites: Please inquire
• ACCN: NM_004756
• Insert Size: 2800 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone has been fully sequenced and found 3 bp deletion within the protein associated with this reference, NM_004756.2:There is a 3 bases deletion (GCA)at position 1464.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004756.2, NP_004747.1
• RefSeq Size: 2853 bp
• RefSeq ORF: 1830 bp
• Locus ID: 9253
• UniProt ID: Q9Y6R0
• Cytogenetics: 19q13.2
• Domains: PID
• Protein Pathways: Notch signaling pathway
• Gene Summary: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.