NAIP (NM_004536) Human Untagged Clone

CAT#: SC303496

NAIP (untagged)-Human NLR family, apoptosis inhibitory protein (NAIP), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NAIP
• Synonyms: BIRC1; NLRB1; psiNAIP
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004536 edited
  AAAGGACGGACAGAGCATTTGTTCTTCAGCCACATACTTTCCTTCCACTGGCCAGCATTC
  TCCTCTATTAGACTAGAACTGTGGATAAACCTCAGAAAATGGCCACCCAGCAGAAAGCCT
  CTGACGAGAGGATCTCCCAGTTTGATCACAATTTGCTGCCAGAGCTGTCTGCTCTTCTGG
  GCCTAGATGCAGTTCAGTTGGCAAAGGAACTAGAAGAAGAGGAGCAGAAGGAGCGAGCAA
  AAATGCAGAAAGGCTACAACTCTCAAATGCGCAGTGAAGCAAAAAGGTTAAAGACTTTTG
  TGACTTATGAGCCGTACAGCTCATGGATACCACAGGAGATGGCGGCCGCTGGGTTTTACT
  TCACTGGGGTAAAATCTGGGATTCAGTGCTTCTGCTGTAGCCTAATCCTCTTTGGTGCCG
  GCCTCACGAGACTCCCCATAGAAGACCACAAGAGGTTTCATCCAGATTGTGGGTTCCTTT
  TGAACAAGGATGTTGGTAACATTGCCAAGTACGACATAAGGGTGAAGAATCTGAAGAGCA
  GGCTGAGAGGAGGTAAAATGAGGTACCAAGAAGAGGAGGCTAGACTTGCATCCTTCAGGA
  ACTGGCCATTTTATGTCCAAGGGATATCCCCTTGTGTGCTCTCAGAGGCTGGCTTTGTCT
  TTACAGGTAAACAGGACACGGTACAGTGTTTTTCCTGTGGTGGATGTTTAGGAAATTGGG
  AAGAAGGAGATGATCCTTGGAAGGAACATGCCAAATGGTTCCCCAAATGTGAATTTCTTC
  GGAGTAAGAAATCCTCAGAGGAAATTACCCAGTATATTCAAAGCTACAAGGGATTTGTTG
  ACATAACGGGAGAACATTTTGTGAATTCCTGGGTCCAGAGAGAATTACCTATGGCATCAG
  CTTATTGCAATGACAGCATCTTTGCTTACGAAGAACTACGGCTGGACTCTTTTAAGGACT
  GGCCCCGGGAATCAGCTGTGGGAGTTGCAGCACTGGCCAAAGCAGGTCTTTTCTACACAG
  GTATAAAGGACATCGTCCAGTGCTTTTCCTGTGGAGGGTGTTTAGAGAAATGGCAGGAAG
  GTGATGACCCATTAGACGATCACACCAGATGTTTTCCCAATTGTCCATTTCTCCAAAATA
  TGAAGTCCTCTGCGGAAGTGACTCCAGACCTTCAGAGCCGTGGTGAACTTTGTGAATTAC
  TGGAAACCACAAGTGAAAGCAATCTTGAAGATTCAATAGCAGTTGGTCCTATAGTGCCAG
  AAATGGCACAGGGTGAAGCCCAGTGGTTTCAAGAGGCAAAGAATCTGAATGAGCAGCTGA
  GAGCAGCTTATACCAGCGCCAGTTTCCGCCACATGTCTTTGCTTGATATCTCTTCCGATC
  TGGCCACGGACCACTTGCTGGGCTGTGATCTGTCTATTGCTTCAAAACACATCAGCAAAC
  CTGTGCAAGAACCTCTGGTGCTGCCTGAGGTCTTTGGCAACTTGAACTCTGTCATGTGTG
  TGGAGGGTGAAGCTGGAAGTGGAAAGACGGTCCTCCTGAAGAAAATAGCTTTTCTGTGGG
  CATCTGGATGCTGTCCCCTGTTAAACAGGTTCCAGCTGGTTTTCTACCTCTCCCTTAGTT
  CCACCAGACCAGACGAGGGGCTGGCCAGTATCATCTGTGACCAGCTCCTAGAGAAAGAAG
  GATCTGTTACTGAAATGTGCATGAGGAACATTATCCAGCAGTTAAAGAATCAGGTCTTAT
  TCCTTTTAGATGACTACAAAGAAATATGTTCAATCCCTCAAGTCATAGGAAAACTGATTC
  AAAAAAACCACTTATCCCGGACCTGCCTATTGATTGCTGTCCGTACAAACAGGGCCAGGG
  ACATCCGCCGATACCTAGAGACCATTCTAGAGATCAAAGCATTTCCCTTTTATAATACTG
  TCTGTATATTACGGAAGCTCTTTTCACATAATATGACTCGTCTGCGAAAGTTTATGGTTT
  ACTTTGGAAAGAACCAAAGTTTGCAGAAGATACAGAAAACTCCTCTCTTTGTGGCGGCGA
  TCTGTGCTCATTGGTTTCAGTATCCTTTTGACCCATCCTTTGATGATGTGGCTGTTTTCA
  AGTCCTATATGGAACGCCTTTCCTTAAGGAACAAAGCGACAGCTGAAATTCTCAAAGCAA
  CTGTGTCCTCCTGTGGTGAGCTGGCCTTGAAAGGGTTTTTTTCATGTTGCTTTGAGTTTA
  ATGATGATGATCTCGCAGAAGCAGGGGTTGATGAAGATGAAGATCTAACCATGTGCTTGA
  TGAGCAAATTTACAGCCCAGAGACTAAGACCATTCTACCGGTTTTTAAGTCCTGCCTTCC
  AAGAATTTCTTGCGGGGATGAGGCTGATTGAACTCCTGGATTCAGATAGGCAGGAACATC
  AAGATTTGGGACTGTATCATTTGAAACAAATCAACTCACCCATGATGACTGTAAGCGCCT
  ACAACAATTTTTTGAACTATGTCTCCAGCCTCCCTTCAACAAAAGCAGGGCCCAAAATTG
  TGTCTCATTTGCTCCATTTAGTGGATAACAAAGAGTCATTGGAGAATATATCTGAAAATG
  ATGACTACTTAAAGCACCAGCCAGAAATTTCACTGCAGATGCAGTTACTTAGGGGATTGT
  GGCAAATTTGTCCACAAGCTTACTTTTCAATGGTTTCAGAACATTTACTGGTTCTTGCCC
  TGAAAACTGCTTATCAAAGCAACACTGTTGCTGCGTGTTCTCCATTTGTTTTGCAATTCC
  TTCAAGGGAGAACACTGACTTTGGGTGCGCTTAACTTACAGTACTTTTTCGACCACCCAG
  AAAGCTTGTCATTGTTGAGGAGCATCCACTTCCCAATACGAGGAAATAAGACATCACCCA
  GAGCACATTTTTCAGTTCTGGAAACATGTTTTGACAAATCACAGGTGCCAACTATAGATC
  AGGACTATGCTTCTGCCTTTGAACCTATGAATGAATGGGAGCGAAATTTAGCTGAAAAAG
  AGGATAATGTAAAGAGCTATATGGATATGCAGCGCAGGGCATCACCAGACCTTAGTACTG
  GCTATTGGAAACTTTCTCCAAAGCAGTACAAGATTCCCTGTCTAGAAGTCGATGTGAATG
  ATATTGATGTTGTAGGCCAGGATATGCTTGAGATTCTAATGACAGTTTTCTCAGCTTCAC
  AGCGCATCGAACTCCATTTAAACCACAGCAGAGGCTTTATAGAAAGCATCCGCCCAGCTC
  TTGAGCTGTCTAAGGCCTCTGTCACCAAGTGCTCCATAAGCAAGTTGGAACTCAGCGCAG
  CCGAACAGGAACTGCTTCTCACCCTGCCTTCCCTGGAATCTCTTGAAGTCTCAGGGACAA
  TCCAGTCACAAGACCAAATCTTTCCTAATCTGGATAAGTTCCTGTGCCTGAAAGAACTGT
  CTGTGGATCTGGAGGGCAATATAAATGTTTTTTCAGTCATTCCTGAAGAATTTCCAAACT
  TCCACCATATGGAGAAATTATTGATCCAAATTTCAGCTGAGTATGATCCTTCCAAACTAG
  TAAAATTAATTCAAAATTCTCCAAACCTTCATGTTTTCCATCTGAAGTGTAACTTCTTTT
  CGGATTTTGGGTCTCTCATGACTATGCTTGTTTCCTGTAAGAAACTCACAGAAATTAAGT
  TTTCGGATTCATTTTTTCAAGCCGTCCCATTTGTTGCCAGTTTGCCAAATTTTATTTCTC
  TGAAGATATTAAATCTTGAAGGCCAGCAATTTCCTGATGAGGAAACATCAGAAAAATTTG
  CCTACATTTTAGGTTCTCTTAGTAACCTGGAAGAATTGATCCTTCCTACTGGGGATGGAA
  TTTATCGAGTGGCCAAACTGATCATCCAGCAGTGTCAGCAGCTTCATTGTCTCCGAGTCC
  TCTCATTTTTCAAGACTTTGAATGATGACAGCGTGGTGGAAATTGCCAAAGTAGCAATCA
  GTGGAGGTTTCCAGAAACTTGAGAACCTAAAGCTTTCAATCAATCACAAGATTACAGAGG
  AAGGATACAGAAATTTCTTTCAAGCACTGGACAACATGCCAAACTTGCAGGAGTTGGACA
  TCTCCAGGCATTTCACAGAGTGTATCAAAGCTCAGGCCACAACAGTCAAGTCTTTGAGTC
  AATGTGTGTTACGACTACCAAGGCTCATTAGACTGAACATGTTAAGTTGGCTCTTGGATG
  CAGATGATATTGCATTGCTTAATGTCATGAAAGAAAGACATCCTCAATCTAAGTACTTAA
  CTATTCTCCAGAAATGGATACTGCCGTTCTCTCCAATCATTCAGAAATAAAAGATTCAGC
  TAAAAACTGCTGAATCAATAATTTGTCTTGGGGCATATTGAGGATGTAAAAAAAGTTGTT
  GATTAATGCTAAAAACCAAATTATCCAAAATTATTTTATTAAATATTGCATACAAAAGAA
  AATGTGTAAGGCTTGCTAAAAAACAAAACAAAACAAAACACAGTCCTGCATACTCACCAC
  CAAGCTCAAGAAATAAATCATCACCAATACCTTTGAGGTCCCTGAGTAATCCACCCCAGC
  TAAAGGCAAACCCTTCAATCAAGTTTATACAGCAAACCCTCCATTGTCCATGGTCAACAG
  GGAAGGGGTTGGGGACAGGTCTGCCAATCTATCTAAAAGCCACAATATGGAAGAAGTATT
  CAATTTATATAATAAATGGCTAACTTAACGGTTGAATCACTTTCATACATGGATGAAACG
  GGTTTAACACAGGATCCACATGAATCTTCTGTGGGCCAAGAGATGTTCCTTAATCCTTGT
  AGAACCTGTTTTCTATATTGAACTAGCTTTGGTACAGTAGAGTTAACTTACTTTCCATTT
  ATCCACTGCCAATATAAAGAGGAAACAGGGGTTAGGGAAAAATGACTTCATTCCAGAGGC
  TTCTCAGAGTTCAACATATGCTATAATTTAGAATTTTCTTATGAATCCACTCTACTTGGG
  TAGAAAATATTTTATCTCTAGTGATTGCATATTATTTCCATATCATAGTATTTCATAGTA
  TTATATTTGATATGAGTGTCTATATCAATGTCAGTGTCCAGAATTTCGTTCCTACCAGTT
  AAGTAGTTTTCTGAACGGCCAGAAGACCATTCGAAATTCATGATACTACTATAAGTTGGT
  AAACAACCATACTTTTATCCTCATTTTTATTCTCACTAAGAAAAAAGTCAACTCCCCTCC
  CCTTGCCCAAGTATGAAATATAGGGACAGTATGTATGGTGTGGTCTCATTTGTTTAGAAA
  ACCACTTATGACTGGGTGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAG
  GCGGGCGAATCATTTGAGGTGAGGAATTCGAGACCAGCCTGGCCAGCATGGTGAAACCCC
  ATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCACATGCCTGTAGTCCCAGCC
  ACTAGGGCGGCTGAGACGCAAGACTTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCC
  AAGATGGCGCCACTGCATTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTGTCTCAAAAC
  AAAAAACAAAACCACTTATATTGCTAGCTACATTAAGAATTTCTGAATATGTTACTGAGC
  TTGCTTGTGGTAACCATTTATAATATCAGAAAGTATATGTACACCAAAACATGTTGAACA
  TCCATGTTGTACAACTGAAATATAAATAATTTTGTCAATTATACCTAAATAAAACTGGAA
  AAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004536 unedited
  GGCCATTTCGAAAATACGACTCCTATAGGGCGGCCGCGAATTCGGCACGAGAAAGGACGG
  ACAGAGCATTTGTTCTTCAGCCACATACTTTCCTTCCACTGGCCAGCATTCTCCTCTATT
  AGACTAGAACTGTGGATAAACCTCAGAAAATGGCCACCCAGCAGAAAGCCTCTGACGAGA
  GGATCTCCCAGTTTGATCACAATTTGCTGCCAGAGCTGTCTGCTCTTCTGGGCCTAGATG
  CAGTTCAGTTGGCAAAGGAACTAGAAGAAGAGGAGCAGAAGGAGCGAGCAAAAATGCAGA
  AAGGCTACAACTCTCAAATGCGCAGTGAAGCAAAAAGGTTAAAGACTTTTGTGACTTATG
  AGCCGTACAGCTCATGGATACCACAGGAGATGGCGGCCGCTGGGTTTTACTTCACTGGGG
  TAAAATCTGGGATTCAGTGCTTCTGCTGTAGCCTAATCCTCTTTGGTGCCGGCCTCACGA
  GACTCCCCATAGAAGACCACAAGAGGTTTCATCCAGATTGTGGGTTCCTTTTGAACAAGG
  ATGTTGGTAACATTGCCAAGTACGACATAAGGGTGAAGAATCTGAAGAGCAGGCTGAGAG
  GAGGTAAAATGAGGTACCAAGAAGAGGAGGCTAGACTTGCATCCTTCAGGAACTGGCCAT
  TTTATGTCCAAGGGATATCCCCTTGTGTGCTCTCAGAGGCTGGCTTTGTCTTTACAGGTA
  AACAGGACACGGTACAGTGTTTTTCCTGTGGTGGATGTTTAGGAAATTGGGAAGAAGAGA
  TGATCCTTGGAAGGAACATGCCAAATGGTTCCCCAAATGTGAATTTCTTCGGAGTAGAAA
  TCCTCAGAGGAAATTACCCAGTATATTTCAAAGCTACAAGGATTTGTTGACATAACGGAA
  GACATTTTGTGAATTCCTGGGTCAGAGAAGAATTACCTATGGCATCAGCTTATTGCAATG
  ACCAGCATC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004536 unedited
  CAATAATGGCACTTCCGGGCCGGAGAGCACTGGGGAGGGGTCACAGGGATGCCCCCGGGA
  TCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTT
  TTTTCCAGTTTTATTTAGGTATAATTGACAAAATTATTTATATTTCAGTTGTACAACATG
  GATGTTCAACATGTTTTGGTGTACATATACTTTCTGATATTATAAATGGTTACCACAAGC
  AAGCTCAGTAACATATTCAGAAATTCTTAATGTAGCTAGCAATATAAGTGGTTTTGTTTT
  TTGTTTTGAGACAGACAGGGTCTTGCTCTGTTGCCCAGGCTGGAATGCAGTGGCGCCATC
  TTGGCTCACTGCACCTTTGCCTCCAGGGTTCAAGCAAGTATTGCGTTTCAGCCTCCCTAT
  TGGCTGGGACTACAGGCATGTGCCACCACACCTGGCTAATTTTTGTATTTTTAATAGAGA
  TGGGGTTTCACCATGCTGGCCACGCTGGCCTCTAATTCCTTTCCTAAAATGATTCACCGG
  ACTCAGCCTTACCAAAGTGCTGGGATTACACGGTGTGAGCCACCTCACCTAACATTCTTG
  GTTTCCTAAACAAATGAAACCACACCTTACAAACTGTCCTATTTTTATACTTGGCAAGGA
  GAGGGGAGTTGCTTTTTTCTAAAAGAAATAGAAATGAGGAAAAAAGTATGGTTGTTTACC
  C
  
• Restriction Sites: Please inquire
• ACCN: NM_004536
• Insert Size: 6000 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: no
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004536.1, NP_004527.1
• RefSeq Size: 6133 bp
• RefSeq ORF: 4212 bp
• Locus ID: 4671
• UniProt ID: Q13075
• Cytogenetics: 5q13.2
• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway
• Gene Summary: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same protein.