CORD2 (CRX) (NM_000554) Human Untagged Clone

CAT#: SC126270

CRX (untagged)-Human cone-rod homeobox (CRX)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CORD2
• Synonyms: CORD2; CRD; LCA7; OTX3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000554 edited
  TAAAATCTCCCCATGTGAGGGGATGTGTTTCCTTCAGCCTCTGCTGTCTGGCCGCTCTGT
  CTAGGTCCTGGGCCACGGGAGAGCCCCGTCCCTCCTTTCTGAAGGCCCCCTGACTTGGGC
  CTCAGTGTCCCCGAAGATCATGATGGCGTATATGAACCCGGGGCCCCACTATTCTGTCAA
  CGCCTTGGCCCTAAGTGGCCCCAGTGTGGATCTGATGCACCAGGCTGTGCCCTACCCAAG
  CGCCCCCAGGAAGCAGCGGCGGGAGCGCACCACCTTCACCCGGAGCCAACTGGAGGAGCT
  GGAGGCACTGTTTGCCAAGACCCAGTACCCAGACGTCTATGCCCGTGAGGAGGTGGCTCT
  GAAGATCAATCTGCCTGAGTCCAGGGTTCAGGTTTGGTTCAAGAACCGGAGGGCTAAATG
  CAGGCAGCAGCGACAGCAGCAGAAACAGCAGCAGCAGCCCCCAGGGGGCCAGGCCAAGGC
  CCGGCCTGCCAAGAGGAAGGCGGGCACGTCCCCAAGACCCTCCACAGATGTGTGTCCAGA
  CCCTCTGGGCATCTCAGATTCCTACAGTCCCCCTCTGCCCGGCCCCTCAGGCTCCCCAAC
  CACGGCAGTGGCCACTGTGTCCATCTGGAGCCCAGCCTCAGAGTCCCCTTTGCCTGAGGC
  GCAGCGGGCTGGGCTGGTGGCCTCAGGGCCGTCTCTGACCTCCGCCCCCTATGCCATGAC
  CTACGCCCCGGCCTCCGCTTTCTGCTCTTCCCCCTCCGCCTATGGGTCTCCGAGCTCCTA
  TTTCAGCGGCCTAGACCCCTACCTTTCTCCCATGGTGCCCCAGCTAGGGGGCCCGGCTCT
  TAGCCCCCTCTCTGGCCCCTCCGTGGGACCTTCCCTGGCCCAGTCCCCCACCTCCCTATC
  AGGCCAGAGCTATGGCGCCTACAGCCCCGTGGATAGCTTGGAATTCAAGGACCCCACGGG
  CACCTGGAAATTCACCTACAATCCCATGGACCCTCTGGACTACAAGGATCAGAGTGCCTG
  GAAGTTTCAGATCTTGTAGAGGACGCAGTCTCCATCTCTCTCCATCGGGCCTCGGGACCC
  TTTCTCTTCTGAATCTGCTTCCCTGCAGTTTAGATCCCGGGATGGCATTCCTGAGAAAGC
  AACCCGAACCAGCTGTCCTTCTGACAGCTCGGTGTTCAGCTTACAGAGACCACCCCTTTC
  CTCCACAGGGAGAGGCTCCTCCCTCTCCTGGGACAGCTCACAGGTCCTAGTGATTCTCTC
  AACCCTAACACCGTCTGGCACGATTGTGACCGCTGAAGTACACCACGAGCTCCAGGCTTC
  AGAAAGTGGTGCTGAGAACTTGCTCCAAGAAGAAGTCAAACCAAACTTGCAGTTGATTTG
  GGGTCATGTTTAGGTCAGAATCACCGTGCCCTTGAACAAGCAGGTAGGGGGGCTTGATAA
  CTTAACTTTCCACGTGGACAGAATTTTTTTTTTTGTTTTGTTTTTGTTTTGCCACTGTGC
  TCTAGCCTGGGTCACAAGAGCGAAACTCCGTCTCAATAATAACAACAACAAAAATAACCC
  AGGAGTGGCTCAAGAGTCCAGTGTGGGATGAAAATATAAACAGAGGAAGACAACATATGT
  CACTGGGGAGGCTGGGGGAGCTAGACAAAATTCACACGGGAGGGGCAGGGATGAGACAAT
  ATTGTGCCCTGGGTCTGTGCAAACGTTGGGACCAGAATCCACTATAAGTTTCATTCTTCG
  GAGACACGGAAGCTCTGCACTGGAGGCCGGGACTCAGGCGTGGAAGAGAATCTTCTCCTT
  ATTCACCGGGGAGGCTGTGTCTTGTGCAAACAAGTCATAGAAACTTGATGGGAGTTGGGG
  AGGGACTGAAGGATGCATGCAAGGTTCTGGGAAGGAGTGAGAAGTAGTGAAGGCCAAGGG
  GCCCCCATCACAGGCCGATGGGGTAAGACTTCGAGAGAGCCTGATCCTGGGGTCTTCTGA
  GACTCCACCAGGAGCCGGAGAGGGCAGGGAGCCAAATCCAGCTAGGAGGTTACAGATTGC
  TTTTCCTGGGCTGGGCTCCTGAGTGTTGGTTCTTCCAGCTGTGCACAGGGGATTTCAAAC
  GTTCTACGTCCTAAAGCCAGGAAGAGTGACAAGGCAGGTGGGGACAGAAGGAAGAAGCCA
  GGAGCCTCCCTGAGAAGGTGTCACCTTATCTGTCCTCCTCTTCCCCACACACTGGCCTCT
  GGGTCCCCCTTCTCTGTCCACCCACAGAGTGAAACCAATTAAAATGTTGGATCTCAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000554 unedited
  NTTGGGGTTTTGGATTTGTNATACGACTTACTATAGGCGGCCGCGNATTCAGATCTGGTA
  CCGGTCCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGGGCCGCTCTGTCTAGGTCC
  TGGGCCACGGGAGAGCCCCGTCCCTCCTTTCTGAAGGCCCCCTGACTTGGGCCTCAGTGT
  CCCCGAAGATCATGATGGCGTATATGAACCCGGGGCCCCACTATTCTGTCAACGCCTTGG
  CCCTAAGTGGCCCCAGTGTGGATCTGATGCACCAGGCTGTGCCCTACCCAAGCGCCCCCA
  GGAAGCAGCGGCGGGAGCGCACCACCTTCACCCGGAGCCAACTGGAGGAGCTGGAGGCAC
  TGTTTGCCAAGACCCAGTACCCAGACGTCTATGCCCGTGAGGAGGTGGCTCTGAAGATCA
  ATCTGCCTGAGTCCAGGGTTCAGGTTTGGTTCAAGAACCGGAGGGCTAAATGCAGGCAGC
  AGCGACAGCAGCAGAAACAGCAGCAGCAGCCCCCAGGGGGCCAGGCCAAGGCCCGGCCTG
  CCAAGAGGAAGGCGGGCACGTCCCCAAGACCCTCCACAGATGTGTGTCCAGACCCTCTGG
  GCATCTCAGATTCCTACAGTCCCCCTCTGCCCGGCCCCTCAGGCTCCCCAACCACGGCAG
  TGGCCACTGTGTCCATCTGGAGCCCAGCCTCAGAGTCCCCTTTGCCTGAGGCGCANCGGG
  CTGGGCTGGTGGCCTCAGGGCCGTCTCTGACCTCCGCCCCCTATGCCATGACCTACGCCC
  CGGCCTCCGCTTTCTGCTCTTCCCCCTCCGCCTATGGGTCTCCGAGCTCCTATTTCAGCG
  GCCTAGACCCCTACCTTTCTCCCTGGTGCCCCAGCTA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000554
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000554.2, NP_000545.1
• RefSeq Size: 2376 bp
• RefSeq ORF: 900 bp
• Locus ID: 1406
• UniProt ID: O43186
• Cytogenetics: 19q13.33
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]