KPNA5 (NM_002269) Human Untagged Clone

CAT#: SC118724

KPNA5 (untagged)-Human karyopherin alpha 5 (importin alpha 6) (KPNA5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KPNA5
• Synonyms: IPOA6; SRP6
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118724 sequence for NM_002269 edited (data generated by NextGen Sequencing)
  ATGGATGCCATGGCTAGTCCAGGGAAAGATAACTATAGAATGAAAAGTTATAAGAATAAA
  GCCCTAAATCCTCAAGAGATGCGTAGACGAAGAGAAGAAGAAGGAATACAGCTTAGAAAA
  CAAAAAAGAGAAGAACAGTTGTTCAAACGCAGAAATGTCTATTTGCCCAGAAATGATGAA
  TCTATGCTTGAAAGTCCTATACAGGATCCAGGTATTAGTTCCACTGTACCCATTCCAGAG
  GAAGAAGTTGTTACTACAGATATGGTTCAGATGATTTTTTCTAATAATGCTGATCAACAG
  CTAACAGCAACACAGAAATTTAGAAAGCTGCTTTCTAAAGAACCTAATCCACCAATAGAT
  CAAGTTATACAGAAACCAGGAGTTGTACAGAGATTTGTGAAATTTCTTGAAAGAAATGAA
  AATTGCACTTTACAATTTGAAGCTGCATGGGCATTAACAAATATAGCATCTGGAACTTTT
  CTGCATACCAAGGTAGTGATTGAAACTGGGGCTGTTCCGATTTTTATCAAACTTCTTAAT
  TCTGAACATGAAGATGTTCAGGAACAGGCTGTTTGGGCACTTGGTAATATTGCTGGTGAC
  AATGCAGAATGCAGAGATTTTGTTTTGAATTGTGAAATACTTCCACCTCTTTTAGAGTTA
  TTAACAAATTCAAACAGACTCACAACAACAAGAAATGCCGTGTGGGCCCTCTCAAATTTA
  TGTAGAGGCAAAAACCCTCCTCCAAACTTTAGTAAGGTTTCACCTTGCTTAAATGTCCTG
  TCACGACTGTTGTTTAGCAGTGACCCAGATGTGTTAGCAGACGTGTGTTGGGCCCTTTCT
  TATCTCTCCGATGGACCCAATGATAAAATTCAAGCAGTCATTGATTCTGGAGTCTGTCGA
  AGATTGGTGGAACTTTTGATGCACAATGATTATAAAGTTGTATCACCTGCATTAAGGGCA
  GTTGGTAATATTGTGACTGGTGATGATATTCAAACACAGGTAATTTTGAATTGTTCTGCA
  TTACCCTGTCTCTTACATTTATTGAGTAGCCCAAAGGAGTCAATTAGAAAAGAAGCCTGC
  TGGACTGTTTCTAACATCACTGCTGGAAATAGAGCTCAGATTCAGGCTGTTATAGATGCA
  AATATTTTTCCTGTTTTGATTGAGATTCTTCAGAAAGCAGAGTTTCGTACCAGAAAAGAA
  GCAGCTTGGGCTATAACTAATGCAACATCAGGAGGTACTCCAGAGCAAATAAGGTATTTG
  GTAGCTTTAGGCTGCATTAAACCACTTTGTGATCTTTTGACTGTTATGGACTCCAAAATA
  GTCCAAGTGGCTTTAAATGGACTTGAAAATATTTTACGTCTTGGAGAACAAGAATCTAAG
  CAGAATGGAATAGGCATTAATCCATACTGTGCTCTCATTGAAGAAGCATATGGTCTGGAT
  AAAATTGAGTTTTTGCAAAGCCATGAAAATCAGGAAATTTACCAGAAGGCATTTGATCTG
  ATTGAACATTACTTTGGTGTAGAAGAAGATGACCCCAGCATTGTACCTCAGGTGGATGAA
  AACCAACAACAGTTTATATTTCAGCAGCAGGAAGCACCAATGGATGGATTTCAACTTTAA
  
  Clone variation with respect to NM_002269.2
  212 a=>g
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002269 unedited
  CATTTGTATACGACTCATATAGGCGGCCGGATTCGCACAGCTACGCTTACGCCAGGGCGG
  AGTGGCGGCCCTTCTGTTACCCGCCACACACGTCGCCGCTGGGGACTGGGAAATCAGGGC
  ATCGGAGAGTGCCACATTAATGGATGCCATGGCTAGTCCAGGGAAAGATAACTATAGAAT
  GAAAAGTTATAAGAATAAAGCCCTAAATCCTCAAGAGATGCGTAGACGAAGAGAAGAAGA
  AGGAATACAGCTTAGAAAACAAAAAAGAGAAGAACAGTTGTTCAAACGCAGAAATGTCTA
  TTTGCCCAGAAATGATGAATCTATGCTTGAAAGTCCTATACAGGATCCAGGTATTAGTTC
  CACTGTACCCATTCCAGAGGAAGAAGTTGTTACTACAGATATGGTTCAGATGATTTTTTC
  TAATAATGCTGATCAACAGCTAACAGCAACACAGAAATTTAGAAAGCTGCTTTCTAAAGA
  ACCTAATCCACCAATAGATCAAGTTATACAGAAACCAGGAGTTGTACAGAGATTTGTGAA
  ATTTCTTGAAAGAAATGAAAATTGCACTTTACAATTTGAAGCTGCATGGGCATTAACAAA
  TATAGCATCTGGAACTTTTCTGCATACCAAGGTAGTGATTGAAACTGGGGCTGTTCCGAT
  TTTTATCAAACTTCTTAATTCTGAACTGNAAGATGTTCAGGAACAGGGCTGTTTGGGCAC
  TTGGTAATATTNGCTGGTGACAATGCAGATGCAGAGATTNTGTTNTGAATTGTGAATACT
  TCCACCTTTTTTTAGAGTATTAACAAATTCAAACAGACTCACACAACAGAAATGGCCGTG
  TGGGCCTCTCAAATTATGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002269
• Insert Size: 4100 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002269.2, NP_002260.2
• RefSeq Size: 2172 bp
• RefSeq ORF: 1620 bp
• Locus ID: 3841
• UniProt ID: O15131
• Cytogenetics: 6q22.1
• Domains: Armadillo_seg, IBB
• Gene Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.