TLR1 (NM_003263) Human Untagged Clone

CAT#: SC118088

TLR1 (untagged)-Human toll-like receptor 1 (TLR1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TLR1
• Synonyms: CD281; rsc786; TIL; TIL. LPRS5
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_003263, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGACTAGCATCTTCCATTTTGCCATTATCTTCATGTTAATACTTCAGATCAGAATACAATTATCTGAAG
  AAAGTGAATTTTTAGTTGATAGGTCAAAAAACGGTCTCATCCACGTTCCTAAAGACCTATCCCAGAAAAC
  AACAATCTTAAATATATCGCAAAATTATATATCTGAGCTTTGGACTTCTGACATCTTATCACTGTCAAAA
  CTGAGGATTTTGATAATTTCTCATAATAGAATCCAGTATCTTGATATCAGTGTTTTCAAATTCAACCAGG
  AATTGGAATACTTGGATTTGTCCCACAACAAGTTGGTGAAGATTTCTTGCCACCCTACTGTGAACCTCAA
  GCACTTGGACCTGTCATTTAATGCATTTGATGCCCTGCCTATATGCAAAGAGTTTGGCAATATGTCTCAA
  CTAAAATTTCTGGGGTTGAGCACCACACACTTAGAAAAATCTAGTGTGCTGCCAATTGCTCATTTGAATA
  TCAGCAAGGTCTTGCTGGTCTTAGGAGAGACTTATGGGGAAAAAGAAGACCCTGAGGGCCTTCAAGACTT
  TAACACTGAGAGTCTGCACATTGTGTTCCCCACAAACAAAGAATTCCATTTTATTTTGGATGTGTCAGTC
  AAGACTGTAGCAAATCTGGAACTATCTAATATCAAATGTGTGCTAGAAGATAACAAATGTTCTTACTTCC
  TAAGTATTCTGGCGAAACTTCAAACAAATCCAAAGTTATCAAATCTTACCTTAAACAACATTGAAACAAC
  TTGGAATTCTTTCATTAGGATCCTCCAGCTGGTTTGGCATACAACTGTATGGTATTTCTCAATTTCAAAC
  GTGAAGCTACAGGGTCAGCTGGACTTCAGAGATTTTGATTATTCTGGCACTTCCTTGAAGGCCTTGTCTA
  TACACCAAGTTGTCAGCGATGTGTTCGGTTTTCCGCAAAGTTATATCTATGAAATCTTTTCGAATATGAA
  CATCAAAAATTTCACAGTGTCTGGTACACGCATGGTCCACATGCTTTGCCCATCCAAAATTAGCCCGTTC
  CTGCATTTGGATTTTTCCAATAATCTCTTAACAGACACGGTTTTTGAAAATTGTGGGCACCTTACTGAGT
  TGGAGACACTTATTTTACAAATGAATCAATTAAAAGAACTTTCAAAAATAGCTGAAATGACTACACAGAT
  GAAGTCTCTGCAACAATTGGATATTAGCCAGAATTCTGTAAGCTATGATGAAAAGAAAGGAGACTGTTCT
  TGGACTAAAAGTTTATTAAGTTTAAATATGTCTTCAAATATACTTACTGACACTATTTTCAGATGTTTAC
  CTCCCAGGATCAAGGTACTTGATCTTCACAGCAATAAAATAAAGAGCATTCCTAAACAAGTCGTAAAACT
  GGAAGCTTTGCAAGAACTCAATGTTGCTTTCAATTCTTTAACTGACCTTCCTGGATGTGGCAGCTTTAGC
  AGCCTTTCTGTATTGATCATTGATCACAATTCAGTTTCCCACCCATCGGCTGATTTCTTCCAGAGCTGCC
  AGAAGATGAGGTCAATAAAAGCAGGGGACAATCCATTCCAATGTACCTGTGAGCTAGGAGAATTTGTCAA
  AAATATAGACCAAGTATCAAGTGAAGTGTTAGAGGGCTGGCCTGATTCTTATAAGTGTGACTACCCGGAA
  AGTTATAGAGGAACCCTACTAAAGGACTTTCACATGTCTGAATTATCCTGCAACATAACTCTGCTGATCG
  TCACCATCGTTGCCACCATGCTGGTGTTGGCTGTGACTGTGACCTCCCTCTGCAGCTACTTGGATCTGCC
  CTGGTATCTCAGGATGGTGTGCCAGTGGACCCAGACCCGGCGCAGGGCCAGGAACATACCCTTAGAAGAA
  CTCCAAAGAAATCTCCAGTTTCATGCATTTATTTCATATAGTGGGCACGATTCTTTCTGGGTGAAGAATG
  AATTATTGCCAAACCTAGAGAAAGAAGGTATGCAGATTTGCCTTCATGAGAGAAACTTTGTTCCTGGCAA
  GAGCATTGTGGAAAATATCATCACCTGCATTGAGAAGAGTTACAAGTCCATCTTTGTTTTGTCTCCCAAC
  TTTGTCCAGAGTGAATGGTGCCATTATGAACTCTACTTTGCCCATCACAATCTCTTTCATGAAGGATCTA
  ATAGCTTAATCCTGATCTTGCTGGAACCCATTCCGCAGTACTCCATTCCTAGCAGTTATCACAAGCTCAA
  AAGTCTCATGGCCAGGAGGACTTATTTGGAATGGCCCAAGGAAAAGAGCAAACGTGGCCTTTTTTGGGCT
  AACTTAAGGGCAGCCATTAATATTAAGCTGACAGAGCAAGCAAAGAAATAG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003263 unedited
  TCACAATTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGAACAGA
  CAAGCAGGTTGTCTTGGGTCTTCATGAACACTAATAGGGGTACCAGGCCCTCTTCCTCGT
  TAGAAGAAATCAGGATAACAAAGGCATATTGGGCACCCCTACAAAAGGAATCTGTATCTG
  TATCAAGATGATCTGAAGAACAGCTTCTACCTTTAGGAATGTCTAGTGTTCCAAAATGAC
  TAGCATCTTCCATTTTGCCATTATCTTCATGTTAATACTTCAGATCAGAATACAATTATC
  TGAAGAAAGTGAATTTTTAGTTGATAGGTCAAAAAACGGTCTCATCCACGTTCCTAAAGA
  CCTATCCCAGAAAACAACAATCTTAAATATATCGCAAAATTATATATCTGAGCTTTGGAC
  TTCTGACATCTTATCACTGTCAAAACTGAGGATTTTGATAATTTCTCATAATAGAATCCA
  GTATCTTGATATCAGTGTTTTCAAATTCAACCAGGAATTGGAATACTTGGATTTGTCCCA
  CAACAAGTTGGTGAAGATTTCTTGCCACCCTACTGTGAACCTCAAGCACTTGGACCTGTC
  ATTTAATGCATTTGATGCCCTGCCTATATGCAAAGAGTTTGGCAATATGTCTCAACTAAN
  NATTCTGGNGTTGAGCACCACACACTTTAGAAAATCTAGTGTGCTGCCAATTGCTCATTT
  GAATATCAGNCAAGTCTTGCTGGTCTTANGAGAGAACTATGGNGAANAAAGAAGACCCTN
  GAGGCCCTTCAAGAACTTAACACTTGAGAGTCTGCACATTGTGTTCCCCCACCAACAAAG
  AATTCCATCTTATTTTGGATGTGTCAGTCAAGACTGTAGCAAATCTGGAACCTATCTATT
  ATCAAAGTGTGCTAGAAGAATACAAATGGTCCTACTTCCCTAGTATTCTGGCGAN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003263 unedited
  CGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTACATTTCATTAATTTTTAA
  TACCACATATAAATGGTGAACTGCGACCCGAAGGTATATATTTTTACCTACATCATACAC
  TCACAATTGTGTTTACATCTATGCTGATGCAAAATAAAGTCATTGTTGGAACTTCCAAAA
  GCAGCAATATCAACAGGAGGAATATTTTTCACTTGATGTGTAATCTATTTCTTTGCTTGC
  TCTGTCAGCTTAATATTAATGGCTGCCCTTAAGTTAGCCCAAAAAAGGCCACGTTTGCTC
  TTTTCCTTGGGCCATTCCAAATAAGTCCTCCTGGCCATGAGACTTTTGAGCTTGTGATAA
  CTGCTAGGAATGGAGTACTGAGGAATGGGTTCCAGCAAGATCAGGATTAAGCTATTAGAT
  CCTTCATGAAAGAGATTGTGATGGGCAAAGTAGAGTTCATAATGGCACCATTCACTCTGG
  ACAAAGTTGGGAGACAAAACAAAGATGGACTTGTAACTCTTCTCAATGCAGGTGATGATA
  TTTTCCACAATGCTCTTGCCAGGAACAAAGTTTCTCTCATGAAGGCAAATCTGCATACCT
  TCTTTCTCTAGGTTTGGCAATAATTCATTCTTCACCCAGAAAGAATCGTGCCCACTATAT
  GAAATAAATGCATGAAACTGGAGATTTCTTTGTAGTTCTTCTAAGGGTATGTTCCTGGCC
  CCTGCGCCGGGTTTGGGTCCACTGGCCACACCATCCTGAGAATCCCAGGCCATATTCCAG
  TACCTGTCCAAGGAGGGCCCATTCACACCCCCCCCCTCATGGGGGCAACAATGGCGACAA
  TCACAAGACTTTTGTCGCAGATAATCCAACTTGGAAAACCCTCTAAAGGGTCCCTTTAAA
  CTTCCGGGTGTCACCCTATAAAATAGGCCACCCTCAAAACTAATTGAACCTGGCTTTATT
  TTACAN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003263
• Insert Size: 2820 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003263.3, NP_003254.2
• RefSeq Size: 2867 bp
• RefSeq ORF: 2361 bp
• Locus ID: 7096
• UniProt ID: Q15399
• Cytogenetics: 4p14
• Domains: TIR, LRRCT, LRR, LRR_TYP
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway
• Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]