CLCA2 (NM_006536) Human Untagged Clone

CAT#: SC116023

CLCA2 (untagged)-Human chloride channel accessory 2 (CLCA2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLCA2
• Synonyms: CACC; CaCC-3; CACC3; CLCRG2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC116023 sequence for NM_006536 edited (data generated by NextGen Sequencing)
  ATGACCCAAAGGAGCATTGCAGGTCCTATTTGCAACCTGAAGTTTGTGACTCTCCTGGTT
  GCCTTAAGTTCAGAACTCCCATTCCTGGGAGCTGGAGTACAGCTTCAAGACAATGGGTAT
  AATGGATTGCTCATTGCAATTAATCCTCAGGTACCTGAGAATCAGAACCTCATCTCAAAC
  ATTAAGGAAATGATAACTGAAGCTTCATTTTACCTATTTAATGCTACCAAGAGAAGAGTA
  TTTTTCAGAAATATAAAGATTTTAATACCTGCCACATGGAAAGCTAATAATAACAGCAAA
  ATAAAACAAGAATCATATGAAAAGGCAAATGTCATAGTGACTGACTGGTATGGGGCACAT
  GGAGATGATCCATACACCCTACAATACAGAGGGTGTGGAAAAGAGGGAAAATACATTCAT
  TTCACACCTAATTTCCTACTGAATGATAACTTAACAGCTGGCTACGGATCACGAGGCCGA
  GTGTTTGTCCATGAATGGGCCCACCTCCGTTGGGGTGTGTTCGATGAGTATAACAATGAC
  AAACCTTTCTACATAAATGGGCAAAATCAAATTAAAGTGACAAGGTGTTCATCTGACATC
  ACAGGCATTTTTGTGTGTGAAAAAGGTCCTTGCCCCCAAGAAAACTGTATTATTAGTAAG
  CTTTTTAAAGAAGGATGCACCTTTATCTACAATAGCACCCAAAATGCAACTGCATCAATA
  ATGTTCATGCAAAGTTTATCTTCTGTGGTTGAATTTTGTAATGCAAGTACCCACAACCAA
  GAAGCACCAAACCTACAGAACCAGATGTGCAGCCTCAGAAGTGCATGGGATGTAATCACA
  GACTCTGCTGACTTTCACCACAGCTTTCCCATGAATGGGACTGAGCTTCCACCTCCTCCC
  ACATTCTCGCTTGTACAGGCTGGTGACAAAGTGGTCTGTTTAGTGCTGGATGTGTCCAGC
  AAGATGGCAGAGGCTGACAGACTCCTTCAACTACAACAAGCCGCAGAATTTTATTTGATG
  CAGATTGTTGAAATTCATACCTTCGTGGGCATTGCCAGTTTCGACAGCAAAGGAGAGATC
  AGAGCCCAGCTACACCAAATTAACAGCAATGATGATCGAAAGTTGCTGGTTTCATATCTG
  CCCACCACTGTATCAGCTAAAACAGACATCAGCATTTGTTCAGGGCTTAAGAAAGGATTT
  GAGGTGGTTGAAAAACTGAATGGAAAAGCTTATGGCTCTGTGATGATATTAGTGACCAGC
  GGAGATGATAAGCTTCTTGGCAATTGCTTACCCACTGTGCTCAGCAGTGGTTCAACAATT
  CACTCCATTGCCCTGGGTTCATCTGCAGCCCCAAATCTGGAGGAATTATCACGTCTTACA
  GGAGGTTTAAAGTTCTTTGTTCCAGATATATCAAACTCCAATAGCATGATTGATGCTTTC
  AGTAGAATTTCCTCTGGAACTGGAGACATTTTCCAGCAACATATTCAGCTTGAAAGTACA
  GGTGAAAATGTCAAACCTCACCATCAATTGAAAAACACAGTGACTGTGGATAATACTGTG
  GGCAACGACACTATGTTTCTAGTTACGTGGCAGGCCAGTGGTCCTCCTGAGATTATATTA
  TTTGATCCTGATGGACGAAAATACTACACAAATAATTTTATCACCAATCTAACTTTTCGG
  ACAGCTAGTCTTTGGATTCCAGGAACAGCTAAGCCTGGGCACTGGACTTACACCCTGAAC
  AATACCCATCATTCTCTGCAAGCCCTGAAAGTGACAGTGACCTCTCGCGCCTCCAACTCA
  GCTGTGCCCCCAGCCACTGTGGAAGCCTTTGTGGAAAGAGACAGCCTCCATTTTCCTCAT
  CCTGTGATGATTTATGCCAATGTGAAACAGGGATTTTATCCCATTCTTAATGCCACTGTC
  ACTGCCACAGTTGAGCCAGAGACTGGAGATCCTGTTACGCTGAGACTCCTTGATGATGGA
  GCAGGTGCTGATGTTATAAAAAATGATGGAATTTACTCGAGGTATTTTTTCTCCTTTGCT
  GCAAATGGTAGATATAGCTTGAAAGTGCATGTCAATCACTCTCCCAGCATAAGCACCCCA
  GCCCACTCTATTCCAGGGAGTCATGCTATGTATGTACCAGGTTACACAGCAAACGGTAAT
  ATTCAGATGAATGCTCCAAGGAAATCAGTAGGCAGAAATGAGGAGGAGCGAAAGTGGGGC
  TTTAGCCGAGTCAGCTCAGGAGGCTCCTTTTCAGTGCTGGGAGTTCCAGCTGGCCCCCAC
  CCTGATGTGTTTCCACCATGCAAAATTATTGACCTGGAAGCTGTAAAAGTAGAAGAGGAA
  TTGACCCTATCTTGGACAGCACCTGGAGAAGACTTTGATCAGGGCCAGGCTACAAGCTAT
  GAAATAAGAATGAGTAAAAGTCTACAGAATATCCAAGATGACTTTAACAATGCTATTTTA
  GTAAATACATCAAAGCGAAATCCTCAGCAAGCTGGCATCAGGGAGATATTTACGTTCTCA
  CCCCAAATTTCCACGAATGGACCTGAACATCAGCCAAATGGAGAAACACATGAAAGCCAC
  AGAATTTATGTTGCAATACGAGCAATGGATAGGAACTCCTTACAGTCTGCTGTATCTAAC
  ATTGCCCAGGCGCCTCTGTTTATTCCCCCCAATTCTGATCCTGTACCTGCCAGAGATTAT
  CTTATATTGAAAGGAGTTTTAACAGCAATGGGTTTGATAGGAATCATTTGCCTTATTATA
  GTTGTGACACATCATACTTTAAGCAGGAAAAAGAGAGCAGACAAGAAAGAGAATGGAACA
  AAATTATTATAA
  
  Clone variation with respect to NM_006536.5
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006536 unedited
  NNGGGTCGAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACCANAAACCTGA
  CACAATGTATGCAGCAGGCTCAGTGTGAGTGAACTGGAGGCTTCTCTACAACATGACCCA
  AAGGAGCATTGCAGGTCCTATTTGCAACCTGAAGTTTGTGACTCTCCTGGTTGCCTTAAG
  TTCAGAACTCCCATTCCTGGGAGCTGGAGTACAGCTTCAAGACAATGGGTATAATGGATT
  GCTCATTGCAATTAATCCTCAGGTACCTGAGAATCAGAACCTCATCTCAAACATTAAGGA
  AATGATAACTGAAGCTTCATTTTACCTATTTAATGCTACCAAGAGAAGAGTATTTTTCAG
  AAATATAAAGATTTTAATACCTGCCACATGGAAAGCTAATAATAACAGCAAAATAAAACA
  AGAATCATATGAAAAGGCAAATGTCATAGTGACTGACTGGTATGGGGCACATGGAGATGA
  TCCATACACCCTACAATACAGAGGGTGTGGAAAAGAGGGAAAATACATTCATTTCACACC
  TAATTTCCTACTGAATGATAACTTAACAGCTGGCTACGGATCACGAGGCCGAGTGTTTGT
  CCATGAATGGGCCCACCTCCGTTGGGGTGTGTTCGATGAGTATAACAATGACAAACCTTT
  CTACATAAATGGGCAAAATCAAATTAAAGTGACAAGGTGTTCATCTGACATCACAGGCAT
  TTTTGTGTGTGAAAAAGGTCCTTGCCCCCAAGAAAACTGTATTATTAGTAAGCTTTTTAA
  AGAAGGATGCACCTTTATCTACAATAGCACCCAAATGCAACTGCATCAATAATGTTCATG
  CANAGTTNNATCTCTGTGGGTGAATTTTGTAAATGCAGTACCCCACACCAAAAGCACCAA
  ACCTACAGAACCAGA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006536 unedited
  CTGTTAATCGCGGCACGCAATTCTAGTGATCGAGTTTTTTTTTTTTTTTTTTTTAAAAAA
  TAATTTTTATTATTATGTTCATAGCCAAAGTGTAAGGAGTTTTCTAATCTACCCCCAAAA
  AGAATTTGTTGATCTACCATGTAAAAATCTTATCTGTATTGTACAAAAACTCAATGCATT
  TTAATACAGTTCTTGATGTTAATTTGACTTTGTTAGTATGTTTTTGTAGTCGAAGGCCAT
  GGGTCTTATATCTAAGAAGGAAGACACTTTGGATATTTATTTATAATAATCTTTGCTCCA
  TTCTCTTTCTTGTCTGCTCTCTTTTTCCTGCTCAAAGTCTGATGTGTCACAACTATATTA
  AGGCAATTTGATTTCTATCAAACCCATTGCTGCTCAATCCCCTCCGATTTAATATACTTT
  TTTTTTTAACCCGGATCTTACCTCTGGCGCCCAATACCAAACTTCCTGTACTCCTCCCCT
  CCCATCTTTCCCGTTTGTATTTTTATCCCTTACTTTCTCTCCCATATTACACCTTCTATT
  TTCACTACCTTTTTTCCTCCCCCCCCCCCCTCTCTTATTCCCCTCCGTAGTTAGTTATCT
  CACTATTCCACTTTCTTTCATTTCCCTCCCCCCACCAGCCTAATATATGATTTTTCACAG
  TCGTCCCCCGCTCTTAGTTCTTCACCTATTTTTTTTCCATCACCCCTTCCCTCCCCCCCC
  TCTATCCCCCCCTTCTCCACCTCACTCACTTCCACTTTTCACACTCTCCCCCTTCCCTCT
  CCCCCCCCCCCTCTCCTCCCTCCTCTCGCGCCACCCTCCTCCCCACCCTTCTCCCTCCTC
  TTCCCCCTTTATCCTATCCCCCCTCCTCCTTTCTTACACTTCTACATTTACCCCCTACCT
  CTACCATATTTCCTCACCCCCATCTCTTACTTCACCTCCCATCCACTTCCTCTCCTCTAA
  CTCTTACTATTCCTTACGCCTTCACT
  
• Restriction Sites: ECoRI-NOT
• ACCN: NM_006536
• Insert Size: 3160 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_006536.4, NP_006527.1
• RefSeq Size: 4007 bp
• RefSeq ORF: 2832 bp
• Locus ID: 9635
• UniProt ID: Q9UQC9
• Cytogenetics: 1p22.3
• Domains: VWA
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: Olfactory transduction
• Gene Summary: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]