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Collagen XI alpha 2 (COL11A2) (NM_080680) Human Tagged ORF Clone
CAT#: RC221097
COL11A2 (Myc-DDK-tagged)-Human collagen, type XI, alpha 2 (COL11A2), transcript variant 1
ORF Plasmid: tGFP
"NM_080680" in other vectors (2)
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Frequently bought together (4)
DDK Rabbit monoclonal antibody, recognizing both N- and C-terminal tags
USD 198.00
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Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Symbol | Collagen XI alpha 2 |
| Synonyms | DFNA13; DFNB53; FBCG2; HKE5; OSMEDA; OSMEDB; PARP; STL3 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC221097 representing NM_080680
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCGGTGCAGCCGCTGCCATCGCCTCCTCCTCCTCCTACCTCTGGTGCTGGGGCTGAGCGCGGCCC CAGGCTGGGCAGGTGCACCCCCTGTGGATGTGCTCCGGGCCCTGAGGTTCCCCTCCCTCCCTGATGGTGT CCGGAGAGCGAAAGGCATCTGTCCAGCTGATGTGGCCTACCGAGTGGCACGACCTGCCCAGCTCAGTGCA CCCACTCGCCAGCTTTTCCCAGGAGGATTTCCCAAAGATTTCTCTCTGCTGACTGTTGTCCGGACCCGCC CTGGTCTCCAAGCTCCCCTCCTGACTCTCTACAGTGCCCAGGGTGTCCGACAGCTGGGCCTGGAGCTGGG CCGACCTGTCCGCTTCCTGTATGAAGACCAGACAGGGCGGCCTCAACCTCCCTCTCAGCCAGTCTTCCGA GGCCTCAGCCTAGCAGATGGCAAGTGGCACCGTGTGGCTGTGGCTGTGAAGGGCCAGTCTGTCACCCTCA TTGTTGACTGCAAGAAGCGAGTCACCCGGCCTCTCCCCCGAAGTGCTCGTCCAGTATTGGACACCCATGG AGTGATCATCTTTGGTGCCCGTATTCTGGATGAAGAAGTCTTTGAGGGTGATGTCCAGGAGCTGGCCATT GTCCCAGGGGTCCAGGCAGCCTATGAATCATGTGAACAGAAGGAGCTGGAATGCGAGGGGGGCCAGAGGG AAAGACCCCAAAACCAACAGCCTCACAGAGCCCAGAGATCTCCACAGCAGCAACCATCAAGACTTCACAG GCCACAAAATCAGGAACCCCAGAGCCAGCCCACTGAGTCTCTCTACTATGACTACGAGCCCCCCTATTAT GATGTGATGACTACGGGGACAACCCCTGATTATCAGGACCCCACCCCAGGTGAAGAGGAAGAAATCCTGG AGTCGAGCCTCTTGCCACCCCTTGAGGAGGAGCAGACAGATCTCCAGGTCCCCCCCACAGCCGACAGGTT CCAGGCAGAGGAATATGGGGAGGGTGGCACAGACCCCCCTGAAGGGCCCTACGATTACACCTATGGCTAT GGGGATGATTATCGTGAGGAGACAGAGCTTGGCCCTGCCCTCTCTGCGGAGACAGCCCACTCAGGAGCCG CTGCCCATGGACCCCGAGGGCTGAAGGGAGAGAAAGGAGAGCCTGCAGTGTTGGAACCTGGTATGCTCGT GGAGGGGCCCCCTGGCCCAGAAGGGCCTGCGGGATTGATTGGTCCCCCTGGCATCCAGGGGAACCCAGGC CCAGTTGGAGACCCTGGAGAGAGGGGCCCCCCTGGCCGAGCAGGGCTCCCTGGATCAGATGGGGCTCCTG GTCCTCCTGGCACATCTCTCATGCTCCCATTCCGGTTTGGCAGTGGTGGGGGTGACAAGGGCCCTGTGGT GGCGGCCCAGGAGGCTCAGGCCCAGGCGATCCTGCAGCAGGCGAGGCTGGCGCTCCGTGGACCCCCTGGC CCCATGGGATACACAGGGCGCCCTGGACCCTTGGGCCAACCTGGGAGCCCTGGCCTGAAAGGAGAGTCTG GAGACTTAGGACCTCAGGGCCCCAGAGGACCTCAGGGCCTCACAGGCTCCCTGGGCAAGGCTGGGCGAAG GGGCCGGGCAGGTGCTGATGGAGCCCGAGGGATGCCTGGAGATCCTGGAGTGAAGGGTGACCGAGGTTTT GATGGACTCCCAGGGCTCCCTGGAGAGAAGGGCCATAGGGGTGATACTGGTGCCCAGGGCCTTCCTGGTC CCCCTGGTGAGGATGGAGAGAGGGGAGATGACGGGGAGATTGGGCCTCGAGGGCTGCCTGGAGAGTCGGG ACCTCGAGGTCTCCTTGGCCCCAAAGGCCCACCTGGTATTCCTGGACCCCCTGGCGTCCGAGGCATGGAT GGTCCCCAGGGCCCCAAAGGGAGCTTGGGACCCCAGGGAGAGCCAGGACCTCCTGGACAACAGGGCACCC CTGGGACCCAGGGTCTTCCCGGGCCCCAGGGTGCCATCGGCCCTCATGGAGAGAAGGGTCCTCAAGGGAA GCCAGGGCTCCCCGGCATGCCTGGCTCAGACGGACCCCCGGGTCACCCAGGGAAGGAAGGTCCCCCTGGA ACCAAAGGAAACCAGGGTCCCTCTGGACCTCAGGGACCTCTAGGATACCCAGGACCTCGAGGGGTCAAGG GTGTGGACGGAATTCGGGGTCTGAAGGGTCATAAGGGTGAGAAGGGTGAGGATGGCTTTCCTGGGTTCAA AGGTGACATAGGCGTGAAAGGTGACAGGGGCGAAGTTGGAGTCCCTGGTTCCAGGGGAGAGGATGGTCCT GAGGGGCCAAAGGGACGCACTGGACCGACTGGAGACCCTGGGCCCCCAGGGCTCATGGGCGAGAAGGGCA AGCTGGGTGTTCCTGGTCTGCCTGGCTATCCTGGACGTCAGGGACCCAAGGGGTCCCTAGGATTTCCTGG CTTTCCTGGTGCCAGTGGAGAGAAGGGAGCCCGGGGCCTGTCGGGGAAGTCAGGGCCTCGGGGAGAACGG GGCCCCACGGGTCCACGGGGTCAGCGGGGACCCCGAGGTGCCACTGGGAAGTCTGGAGCTAAGGGAACAT CTGGTGGTGATGGCCCCCATGGCCCCCCTGGAGAGAGGGGCCTCCCTGGACCTCAGGGTCCCAACGGGTT TCCTGGACCGAAAGGACCCCCGGGCCCCCCTGGGAAGGACGGGCTGCCGGGACACCCAGGCCAAAGAGGA GAAGTGGGTTTCCAAGGGAAGACCGGCCCCCCTGGTCCTCCAGGAGTGGTGGGACCTCAGGGAGCAGCAG GAGAAACCGGCCCTATGGGGGAGAGAGGTCACCCAGGCCCCCCGGGGCCCCCTGGAGAGCAGGGACTACC TGGGACAGCTGGAAAAGAAGGAACAAAGGGTGACCCTGGTCCCCCTGGGGCCCCAGGGAAGGATGGTCCT GCTGGTCTGAGGGGATTCCCAGGAGAGAGAGGCCTCCCAGGCACTGCTGGTGGACCTGGTTTGAAGGGGA ATGAAGGTCCGTCTGGCCCCCCTGGCCCTGCAGGCTCCCCTGGGGAACGAGGTGCAGCAGGATCAGGGGG ACCCATTGGTCGCCAGGGGCGCCCAGGCCCGCAGGGTCCCCCTGGAGCAGCAGGAGAGAAAGGTGTCCCA GGTGAGAAGGGCCCCATTGGCCCGACTGGCCGAGATGGAGTGCAGGGTCCTGTGGGGCTTCCTGGTCCTG CTGGGCCTCCAGGTGTGGCTGGAGAGGATGGAGACAAGGGTGAGGTGGGGGACCCCGGACAGAAGGGCAC CAAAGGGAACAAGGGTGAACATGGCCCTCCTGGACCCCCTGGACCCATTGGTCCTGTGGGGCAGCCTGGA GCAGCGGGAGCAGATGGGGAGCCCGGAGCTCGGGGACCCCAGGGACACTTTGGAGCCAAAGGTGATGAAG GAACAAGAGGATTCAATGGGCCCCCAGGACCCATTGGCCTACAGGGTTTGCCAGGCCCCTCTGGGGAGAA GGGAGAAACAGGAGATGTGGGTCCTATGGGACCACCTGGCCCCCCAGGACCTCGAGGTCCAGCTGGACCC AATGGCGCTGATGGCCCACAAGGTCCCCCAGGAGGTGTTGGGAACCTGGGTCCCCCTGGAGAGAAGGGGG AACCAGGAGAGTCAGGATCTCCAGGGATCCAGGGCGAGCCAGGTGTCAAGGGTCCACGCGGGGAACGTGG AGAGAAAGGAGAGTCGGGGCAGCCAGGAGAGCCAGGGCCACCAGGCGCTAAAGGCCCACAGGGCGATGAT GGCCCCAAAGGGAACCCTGGTCCTGTTGGTTTTCCTGGTGACCCTGGCCCCCCTGGAGAAGGTGGCCCTC GGGGCCAGGATGGTGCTAAGGGTGACCGAGGCGAGGATGGTGAGCCAGGACAGCCTGGATCCCCTGGTCC CACCGGGGAGAATGGACCCCCAGGGCCACTTGGAAAGCGAGGTCCTGCTGGCTCGCCTGGTTCCGAGGGG CGACAAGGAGGGAAGGGAGCCAAGGGAGATCCTGGCGCTATAGGTGCCCCGGGGAAGACAGGCCCGGTGG GTCCTGCAGGCCCAGCAGGGAAACCTGGCCCTGATGGTCTGAGGGGGCTCCCAGGCTCAGTGGGTCAGCA AGGCCGACCTGGAGCTACAGGCCAGGCTGGGCCCCCAGGTCCTGTGGGACCCCCAGGGCTGCCTGGTCTC CGGGGCGATGCTGGAGCCAAGGGAGAGAAGGGCCACCCAGGTCTCATTGGACTGATTGGGCCCCCGGGTG AGCAGGGAGAGAAGGGAGATCGGGGACTTCCTGGGCCTCAGGGCTCCCCTGGGCAGAAGGGTGAGATGGG TATCCCAGGAGCATCCGGCCCCATTGGTCCTGGAGGTCCCCCCGGCCTCCCCGGACCTGCTGGCCCCAAA GGAGCCAAAGGAGCCACAGGCCCAGGCGGACCCAAGGGAGAGAAGGGTGTGCAGGGCCCTCCAGGACACC CGGGTCCCCCAGGCGAGGTGATCCAGCCACTGCCCATTCAGATGCCCAAGAAGACTCGGCGCTCGGTGGA TGGAAGCCGTCTGATGCAGGAAGATGAGGCCATACCGACCGGGGGAGCCCCCGGCAGTCCTGGGGGGCTG GAGGAGATCTTTGGCTCACTCGACTCCCTGCGGGAGGAGATCGAGCAGATGAGGCGGCCAACAGGGACCC AGGACAGCCCTGCTCGCACCTGCCAGGACCTGAAGCTGTGCCACCCAGAGCTTCCCGATGGAGAGTACTG GGTCGACCCCAACCAGGGCTGTGCTCGGGATGCCTTCCGAGTTTTCTGCAACTTCACAGCAGGGGGTGAG ACCTGTGTGACGCCTAGGGATGACGTCACGCAGTTCTCTTACGTGGACTCAGAGGGCTCCCCAGTGGGTG TGGTCCAGCTCACCTTCCTGCGGCTGCTCAGCGTCTCAGCCCACCAGGACGTCTCCTACCCCTGCTCTGG AGCAGCCCGTGACGGTCCCCTGAGACTCCGTGGGGCCAATGAGGATGAGCTGAGCCCGGAGACTAGCCCC TATGTCAAAGAATTCAGAGATGGCTGCCAGACACAGCAAGGCCGGACGGTGCTGGAGGTGCGAACGCCTG TGCTGGAGCAGCTGCCAGTGCTGGATGCCTCCTTCTCAGACCTGGGAGCCCCACCGAGGCGGGGAGGGGT GCTGCTGGGGCCTGTCTGCTTCATGGGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC221097 representing NM_080680
Red=Cloning site Green=Tags(s) MERCSRCHRLLLLLPLVLGLSAAPGWAGAPPVDVLRALRFPSLPDGVRRAKGICPADVAYRVARPAQLSA PTRQLFPGGFPKDFSLLTVVRTRPGLQAPLLTLYSAQGVRQLGLELGRPVRFLYEDQTGRPQPPSQPVFR GLSLADGKWHRVAVAVKGQSVTLIVDCKKRVTRPLPRSARPVLDTHGVIIFGARILDEEVFEGDVQELAI VPGVQAAYESCEQKELECEGGQRERPQNQQPHRAQRSPQQQPSRLHRPQNQEPQSQPTESLYYDYEPPYY DVMTTGTTPDYQDPTPGEEEEILESSLLPPLEEEQTDLQVPPTADRFQAEEYGEGGTDPPEGPYDYTYGY GDDYREETELGPALSAETAHSGAAAHGPRGLKGEKGEPAVLEPGMLVEGPPGPEGPAGLIGPPGIQGNPG PVGDPGERGPPGRAGLPGSDGAPGPPGTSLMLPFRFGSGGGDKGPVVAAQEAQAQAILQQARLALRGPPG PMGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGPQGLTGSLGKAGRRGRAGADGARGMPGDPGVKGDRGF DGLPGLPGEKGHRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMD GPQGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEGPPG TKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDGP EGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGER GPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRG EVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGP AGLRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGRQGRPGPQGPPGAAGEKGVP GEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPG AAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGP NGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGEKGESGQPGEPGPPGAKGPQGDD GPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEG RQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGL RGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPK GAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGL EEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGE TCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGAARDGPLRLRGANEDELSPETSP YVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFSDLGAPPRRGGVLLGPVCFMG TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_080680 |
| ORF Size | 5208 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_080680.1, NP_542411.1 |
| RefSeq Size | 6414 bp |
| RefSeq ORF | 5211 bp |
| Locus ID | 1302 |
| UniProt ID | P13942 |
| Cytogenetics | 6p21.32 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | ECM-receptor interaction, Focal adhesion |
| MW | 169.2 kDa |
| Gene Summary | This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009] |
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