Foxp1 (NM_001197321) Mouse Untagged Clone

CAT#: MC228636

Foxp1 (untagged) - Mouse forkhead box P1 (Foxp1), transcript variant 2

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Foxp1
• Synonyms: 3110052D19Rik; 4932443N09Rik; AI461938; AW494214
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC228636 representing NM_001197321
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGATGCAAGAATCTGGGTCTGAGACAAAAAGTAACGGATCAGCCATCCAGAACGGGTCCAGCGGTGGCA
  ACCACTTACTAGAGTGCGGGGCACTTCGTGACACTCGGTCCAACGGAGAGGCACCAGCGGTGGACCTGGG
  GGCAGCCGACCTTGCCCACGTCCAGCAGCAGCAACAGCAGCAGCAACAACAGCAGCAGCAGCAACAGCAG
  CAGCAGCAGCAGCAAGTTAGTGGATTAAAGTCTCCCAAGAGGAATGACAAGCAACCAGCTCTTCAGGTTC
  CCGTGTCAGTGGCTATGATGACACCTCAGGTTATCACTCCTCAACAAATGCAGCAGATCCTCCAGCAGCA
  GGTGCTGAGCCCCCAGCAGCTCCAGGTTCTCCTCCAGCAGCAGCAGGCCCTCATGCTTCAACAGCAGCTT
  CAAGAATTTTATAAAAAACAACAGGAACAGTTGCAGCTTCAACTTCTCCAACAGCAACATGCTGGAAAAC
  AGCCGAAAGAGCAGCAGGTGGCTACCCAGCAGTTGGCTTTCCAGCAGCAGCTTCTCCAGATGCAGCAGCT
  GCAGCAGCAGCACCTCTTGTCTCTCCAGCGCCAAGGCCTCCTAACAATTCAGCCGGGGCAGCCTGCCCTT
  CCCCTCCAACCCCTCGCTCAAGGCATGATTCCAACGGAACTGCAGCAGCTCTGGAAAGAAGTGACAAGTG
  CCCACACTGCAGAGGAAACCACAAGCAGCAACCACAGCAGCCTAGACCTGACCAGCACATGTGTCTCGTC
  CTCGGCACCTTCCAAGTCCTCCCTAATCATGAACCCGCATGCCTCTACCAATGGACAGCTCTCGGTCCAC
  ACTCCCAAAAGGGAAAGCTTGTCCCACGAGGAGCACCCCCACAGCCACCCTCTCTATGGACATGGCGTAT
  GCAAGTGGCCAGGCTGTGAGGCGGTTTGTGACGACTTCCCAGCCTTTCTAAAACATCTCAACAGTGAGCA
  TGCGCTGGACGATAGAAGCACAGCTCAATGTAGAGTACAAATGCAGGTTGTACAGCAGTTAGAGCTACAG
  CTTGCAAAAGACAAAGAGCGCCTGCAAGCCATGATGACCCACCTGCATGTGAAGTCTACAGAACCCAAAG
  CTGCCCCTCAGCCCCTGAATCTGGTATCAAGTGTCACCCTCTCCAAGTCTGCCTCAGAGGCTTCTCCACA
  GAGCTTACCTCATACTCCAACAACCCCCACCGCCCCCCTGACTCCTGTCACCCAAGGCCCCTCCGTCATC
  ACCACCACCAGCATGCACACGGTGGGACCTATCCGCAGGCGGTACTCAGACAAATACAACGTGCCCATTT
  CTTCAGCAGATATTGCGCAGAACCAAGAATTTTATAAGAACGCGGAAGTTAGACCACCATTTACATATGC
  ATCTTTAATCAGGCAGGCCATTCTCGAATCTCCAGAAAAGCAGCTAACACTAAACGAAATCTATAACTGG
  TTCACACGAATGTTTGCTTACTTCCGACGCAATGCAGCCACGTGGAAGAATGCAGTGCGTCATAATCTTA
  GTCTCCACAAGTGTTTTGTGCGAGTAGAGAACGTTAAAGGGGCAGTATGGACAGTGGATGAAGTAGAGTT
  CCAAAAACGGAGGCCACAAAAGATCAGTGGTAACCCTTCCCTTATTAAAAACATGCAGAGCAGCCACGCC
  TACTGCACACCTCTCAATGCAGCTTTACAGGCTTCCATGGCTGAGAATAGTATACCTCTGTACACTACCG
  CTTCCATGGGAAATCCCACTCTGGGCAGCCTGGCCAGTGCCATCCGGGAGGAGCTGAACGGGGCCATGGA
  GCACACCAACAGCAACGAGAGTGACAGCAGTCCAGGCAGATCCCCTATGCAAGCTGTGCACCCCATACAC
  GTCAAAGAAGAACCCCTCGACCCCGAGGAAGCTGAAGGCCCTCTGTCCTTAGTGACAACAGCCAACCACA
  GTCCAGATTTTGACCATGACAGAGATTACGAAGACGAACCAGTAAATGAGGACATGGAGTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001197321
• Insert Size: 2022 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001197321.1, NP_001184250.1
• RefSeq Size: 7042 bp
• RefSeq ORF: 2022 bp
• Locus ID: 108655
• UniProt ID: P58462
• Cytogenetics: 6 D3
• Gene Summary: Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (PubMed:11358962, PubMed:14701752). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2 (PubMed:11358962, PubMed:22675208). Essential transcriptional regulator of B-cell development (PubMed:16819554). Involved in regulation of cardiac muscle cell proliferation (PubMed:20713518). Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins (PubMed:18667151, PubMed:18662545). Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3 (PubMed:20175877). Negatively regulates the differentiation of T follicular helper cells T(FH)s (PubMed:24859450). Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (PubMed:23946441). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity).[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.