Hps6 (NM_176785) Mouse Untagged Clone

CAT#: MC221755

Hps6 (untagged) - Mouse Hermansky-Pudlak syndrome 6 (Hps6), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Hps6
• Synonyms: 5330434M19Rik; BLOC2; ru
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC221755 representing NM_176785
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAAGCGTGCAGGAACTCTGCGCCTGCTTTCGGATCTGAGCAACTTCACCGGCGCGGCCCGGCTCCGCG
  AGTTGTTGGCGGGGGACCCAGCTGTCCTAGTCCGCTGCAGCCCTGACGGCCGCCACTTGCTGCTATTAAG
  ACCCCCCGGATCGCCCGCCCCACAGCTTCTAGTGGCTGTGCGTGGGCCCGGCCTGCCGCTGGAGCGTGCC
  TGGCCGGAGGGCGACCCCTCGCCGCTGGACGTCTTTTTCGTGCCGTGGCTGGCGCGACCCGCGCTGATCT
  TGGTATGGGAGAGTGGCCTAGCAGAGGTTTGGGGCGTGGGGATGGAGCCTGGATGGAAGCTACTTCAGAG
  CACTGAGCTGTGTCCGGATGGTGGAGCCCGCGTGATGGCCGTGGCCGCAACCCGAGGCCGCCTAGTTTGG
  TGCGAGGAGCGTCAGCCGGGTGTTAAGGACCAACCAGAGCAGCTTTCAACGGCCTTCAGCCACCGTGTGT
  GCTTCAAGACCCTGGAAACCAGCGGGGAGGCTGGCACCAAACTAGGCTGCACCCACATCCTGCTACACCA
  TTGCCCCCTTTTTGGACTGATAGCCTCCCGCAAGGACCTCTTCCTGGTGCCTACTACCAACACTTGGTCT
  GGTGTGGCCCACCTTCTGCTCATCTGGAGCCCAAGCAAGGGGAAGGTAATAGTTGCTGCTCCATCTCTTG
  GTCTTTCACACAGTAAAAGCCTGAATCCCAAACAAGGGGACACTTGGGACTTCCGGACCCTGCTGCGAGG
  CCTTCCTGGATTCCTGTCCCCCAGGGAGCCACTGGCTGTACACACTTGGGCCCCATCTTCGCAGGGCTTG
  TTGTTGCTTGACTTGAAAGGGAAGGTGAGCCTAGTGCAGTGCCATGGTGGTACTCGAACCGTGGGAATCC
  TGCAGGAGGCCCCTGTAAGCCTAAAAGGGTCTGCAGCCCTGGGGACATTTCACGGCACTTTAGCCTGTGT
  CCTGGGCTCCACCTTGGAACTACTGGACATGAGCAGTGGGCGGCTGTTGGAAAAAAAGGTTCTCAGTACA
  GACAGAGTACATTTGCTGGAGCCTCCAGCCCCGGGCATGAAGAACGAGGAAGAGCTGGAGACCCGAGGAG
  CCCTACGATTGCTTTCAGCCTTGGGTCTCTTTTGTGTGTGTTGGGAAACTCCCCAAGGCCTTGAGCTGCC
  TTCAGACAAGGACCTGGTGTTTGAGGAGGCCTGTGGGTACTACCAGCGTCGGAGCCTTCGAGGTACCCAG
  CTTACCCCAGAAGAACTGAGACACAACAGCATGTTTCGGGCACCTCAGGCCCTGGCCTCCATCCTCCAGG
  GCCACCTGCCCCCGTCTACACTCCTGACAACCCTGAGGGCTGAGCTCCGGGATTATCGTAGTATAGAACA
  GCTCAAGGCCCAGCTGGTGGCTGGGGACGATGAGGAGGCTGGCTGGACTGAGTTAGCGGAGCACGAGGTG
  GCCCGCCTGCTGAGAACCCAGTTGACAGGAGACCAGCTGGCCCAATTCAACACCATTTTCCAAGCCCTTC
  CTACAGCAGCTTGGGGTGCCACCCTCCAGGCACTGCAGCTCCAGCCAGATAGGAGTGGCAGGCTGAGGTC
  CCAAGCACCCCCGGATGTATGGAAGAAGGTCCTAAGGGCTCCAACAGCTGGAAAGGAACATCCCAATGGA
  ATACTGCCGCCCTTTGAACTCCTGTGTCAGTGCCTGGGCCAGCTCGAGCCTCAGTGGCTCCCCCCATTTG
  TGAAACTGGCACAGCAGCAGGGTGGCCCCGGCTGGGGGGCTGAAGGCCCCAGTCTGCCCCTTTACCGCCG
  AGCCCTGGCAGTGCTAGGTGAGGAAGGGAAGAGGCCTGAGGCTCTGGAACTCGAGTTGCTTTTGGGCAGT
  GGGCGACCCAAAGCCGTGCTACAAGCTGTAAGGCAGCTGATAAAGAAAGAAGAGTGGGAACGGGCTCTGG
  AAGCCGGGCTGGCCCTGGATGCCTCCAGCCCCCTGCTTCGAAGTGAGATCTTTAAGCTGCTGCTGGCAGA
  GTTTGCCCAGCACCGCCGCCTGGATGCACACCTCCCTCTCCTCTGTCGCCTGTGCCCACCGGAAGTGGCT
  CCACATGAGCTCCTACTTCTGCTGAGGACACATCTCCCAGATGATGAGGGAACCACCCCTTTCCCTGAGC
  CTGGGGCAGAGCCCCCTCTCACAGTGGGCTTGGTCAGAGCCCTGCTAGAACAGACTGGGGCTCAAGGAAG
  GCCGTCTGGCCCAGTTCAAAGCACCTATGAGGACATCTTATGGGACCCAGGCACTCCACCCCCTACACCA
  CCTCGTGGACCCACTGCTTCTCTCCCGGCATCAGACCATCCAGGACAAGAAGCCTGGGTACCACCTGGAC
  AAGGGCTCGGTGCAGCTGATGTGGGAGTTCATTTGTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_176785
• Insert Size: 2418 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_176785.3, NP_789742.2
• RefSeq Size: 2696 bp
• RefSeq ORF: 2418 bp
• Locus ID: 20170
• UniProt ID: Q8BLY7
• Cytogenetics: 19 38.75 cM
• Gene Summary: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (By similarity). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619).[UniProtKB/Swiss-Prot Function]