Prdm6 (NM_001033281) Mouse Untagged Clone

CAT#: MC219569

Prdm6 (untagged) - Mouse PR domain containing 6 (Prdm6), (10ug)


  "NM_001033281" in other vectors (4)

Reconstitution Protocol

USD 833.00

In Stock*

Size
    • 10 ug

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Frequently bought together (2)
TurboFectin Transfection Reagent (1 mL in 1 vial)
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USD 59.00

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Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Symbol Prdm6
Synonyms Gm92; PRISM
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC219569 representing NM_001033281
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGCTGAAGCCGGGGGATCCCGGCGGCTCGGCCTTCCTCAAAGTGGACCCAGCTTACCTGCAGCACTGGC
AGCAACTCTTCCCGCACGGAGGCGGCGGCGGCGGCCCGCTCAAAGCCAGTGGCGCCGCGCTCGCCCTGGG
CGCCCCACAGCCCCTGCAGCCACCGCCACCGCCGCCGCCTCCTCCTCCCGAGCGCGCCGAGCCTCCTCCA
GACGGCCTGCGGCCGCGGCCTGCCTCGCTCTCGTCCACCCCGGCTCCTTCCTCCACCTCTGCCTCTTCTG
CCTCTTCCTGCGCCGCAGCCGCGGCCGCCGCTGCGCTGGCGGGTCTCTCGGCCCTGCCGGTGGCACAGAT
GCCGGTGTTCGCTCCTCTAGCTGCTGCTGCTGTGGCCGCGGAGCCACTGCCCCCAAAGGACCTGTGCCTC
GGCGCCTCCGCCGGCCCCGGGCCGGCCAAGTGCGGCGGCGGCGGTGGCAGCGTGGGGGACGGCCGTGGCG
TCCCACGTTTCCGCTGCAGCGCGGAGGAGCTGGACTATTACCTGTACGGGCAGCAGCGCATGGAAATCAT
CCCGCTCAACCAGCACACCAGCGACCCCAACAACCGTTGCGATATGTGCGCGGACAACCGTAACGGGGAG
TGCCCCATGCACGGGCCACTGCACTCGCTGCGCCGGCTCGTGGGCACCAGCAGCGCGGCCGCCGCTGCAC
CCCCGCCGGAGCTGCCCGAGTGGCTTCGGGATCTGCCGCGGGAGGTGTGCCTGTGTACCAGCACGGTGCC
AGGCCTGGCGTATGGCATCTGTGCCGCGCAGAGGATCCAGCAGGGCACCTGGATTGGGCCCTTCCAGGGC
GTGCTTCTGTCCCCGGAGAAAGTGCAGACCGGCGTAGTGAGGAACACGCAGCATCTCTGGGAGATATATG
ACCAAGATGGGACACTTCAGCACTTTATTGATGGTGGGGAGCCTAGTAAGTCGAGCTGGATGAGGTATAT
CCGATGTGCAAGGCACTGTGGAGAACAGAATCTAACAGTAGTTCAGTACAGGTCGAATATATTCTACCGA
GCCTGTATAGATATCCCCAGGGGCACCGAGCTCCTGGTGTGGTACAATGACAGCTATACATCTTTCTTTG
GGATCCCTTTACAATGCATTGCCCAGGATGAAAACTTGAACGTCCCTTCCACCGTAATGGAAGCCATGTG
CCGACAGGATGCCCTGCAGCCCTTCAACAAAAGCAGCAAGCTTTCTCCCTCGGGCCAGCAGCGCTCCGTG
GTTTTCCCACAGACTCCCTGCAGCAGGAATTTCTCCCTCTTGGATAAATCTGGGCCCATGGAGGCAGGAT
TTAACCAAATCAACGTGAAGAATCAGAGGGTCCTGGCGAGCCCAACCTCAACCAGCCAGCTGCACTCGGA
GTTCAGCGACTGGCATCTCTGGAAGTGCGGCCAGTGCTTTAAGACTTTCACGCAGCGCATTCTCCTGCAG
ATGCATGTGTGCACGCAGAACCCCGACAGACCCTACCAGTGTGGCCACTGCTCACAGTCCTTTTCCCAGC
CGTCAGAACTGAGGAACCACGTAGTCACTCACTCCAGTGACCGGCCTTTCAAGTGCGGCTACTGTGGCCG
TGCGTTTGCCGGAGCCACCACCCTCAACAACCACATCCGGACCCACACTGGAGAAAAGCCCTTCAAGTGC
GAGAGGTGCGAAAGGAGCTTCACCCAGGCCACGCAGCTGAGTCGACACCAGCGCATGCCCAATGAGTGCA
AGCCGATAACCGAGAGCCCGGAATCAATCGAAGTGGATTAA


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Chromatograms CHROMATOGRAMS
Sequencher program is needed, download here.
Restriction Sites SgfI-MluI     
ACCN NM_001033281
Insert Size 1791 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001033281.3, NP_001028453.1
RefSeq Size 2601 bp
RefSeq ORF 1791 bp
Locus ID 225518
UniProt ID Q3UZD5
Cytogenetics 18 D1
Gene Summary Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression (PubMed:16537907, PubMed:17662997). Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells (PubMed:27181681, PubMed:16537907, PubMed:17662997). Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a (PubMed:16537907). According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (PubMed:17662997).[UniProtKB/Swiss-Prot Function]

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