Socs4 (NM_080843) Mouse Untagged Clone

CAT#: MC215730

Socs4 (untagged) - Mouse suppressor of cytokine signaling 4 (Socs4), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Socs4
• Synonyms: 3110032M18Rik; A730004F22Rik; AI427843; AU015727; AU015859; Socs7
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC215730 representing NM_080843
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCTGAAAACAATAGTAAAAATGTAGATGTACGGCCTAAAACAAGTCGGAGTCGAAGTGCTGACAGGA
  AGGATGGTTATGTGTGGAGTGGAAAGAAGTTGTCTTGGTCCAAAAAGAGTGAGAGTTGTTCTGAATCTGA
  AGCCATAGGTACTGTTGAGAATGTTGAAATTCCTCTAAGAAGCCAAGAAAGGCAGCTTAGCTGTTCGTCC
  ATTGAGTTGGACTTAGATCATTCCTGTGGGCATAGATTTTTAGGCCGATCCCTTAAACAGAAACTGCAAG
  ATGCGGTGGGGCAGTGTTTTCCAATAAAGAATTGTAGTGGCCGACACTCTCCAGGGCTTCCATCTAAAAG
  AAAGATTCATATCAGTGAACTCATGTTAGATAAGTGCCCTTTCCCACCTCGCTCAGATTTAGCCTTTAGG
  TGGCATTTTATTAAACGACACACTGTTCCTATGAGTCCCAACTCAGATGAATGGGTGAGTGCAGACCTGT
  CTGAGAGGAAACTGAGAGATGCTCAGCTGAAACGAAGAAACACAGAAGATGACATACCCTGTTTCTCACA
  TACCAATGGCCAGCCTTGTGTCATAACTGCCAACAGTGCTTCGTGTACAGGTGGTCACATAACTGGTTCT
  ATGATGAACTTGGTCACAAACAACAGCATAGAAGACAGTGACATGGATTCAGAGGATGAAATTATAACGC
  TGTGCACAAGCTCCAGAAAAAGGAATAAGCCCAGGTGGGAAATGGAAGAGGAGATCCTGCAGTTGGAGGC
  ACCTCCTAAGTTCCACACCCAGATCGACTACGTCCACTGCCTTGTTCCAGACCTCCTTCAGATCAGTAAC
  AATCCGTGCTACTGGGGTGTCATGGACAAATATGCAGCCGAAGCTCTGCTGGAAGGAAAGCCAGAGGGCA
  CCTTTTTACTTCGAGATTCAGCGCAGGAAGATTATTTATTCTCTGTTAGTTTTAGACGCTACAGTCGTTC
  TCTTCATGCTAGAATTGAGCAGTGGAATCATAACTTTAGCTTTGATGCCCATGATCCTTGTGTCTTCCAT
  TCTCCTGATATTACTGGGCTCCTGGAACACTATAAGGACCCCAGTGCCTGTATGTTCTTTGAGCCGCTCT
  TGTCCACTCCCTTAATCCGGACGTTCCCCTTTTCCTTGCAGCATATTTGCAGAACGGTTATTTGTAATTG
  TACGACTTACGATGGCATCGATGCCCTTCCCATTCCTTCGCCTATGAAATTGTATCTGAAGGAATACCAT
  TATAAATCAAAAGTTAGGTTACTCAGGATTGATGTGCCAGAGCAGCAGTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_080843
• Insert Size: 1311 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_080843.2, NP_543119.2
• RefSeq Size: 2154 bp
• RefSeq ORF: 1311 bp
• Locus ID: 67296
• UniProt ID: Q91ZA6
• Cytogenetics: 14 C1
• Gene Summary: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).[UniProtKB/Swiss-Prot Function]