Hexim1 (NM_138753) Mouse Untagged Clone

CAT#: MC212443

Hexim1 (untagged) - Mouse hexamethylene bis-acetamide inducible 1 (Hexim1), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Hexim1
• Synonyms: 7330426E13Rik; CLP-1; Clp1; HIS1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC212443 representing NM_138753
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCCGAGCCACTCTTGACAGAACATCAACACCAGCCTCAAACTAGCAACTGTACAGGTGCTGCTGTTG
  TCCATGAAGAGCATACCTCTGAGCGCCCCCCAAGCGCGGAGGAACGGGTGCCCAAGGAGGACAGTAGGTG
  GCAATCGAGAGCGTCCTTGCAGTCCGGTAGCCGTCCAGGGCAGGAGGGAGAAGGGGGCCTGAAGCACCAG
  CTGCCCCCATTGCAGACGAATGCCTGTCCAGAATTGAGCTCCCTGGAGAAGGGCGAGAAGGGCCAGAATG
  GGGAGGACTTATCCACTGGCGGTGCCTCCCCGTCGGCGGAGGGAGAGCCGATGTCAGAGTCCCTCGTGCA
  GCCAGGTCATGACTCGGAGGCCACCAAGCAGGAGGCTCCTGCCGCCGGAGGCGAGGAGCCATGGGGACAG
  CAACAGAGACAGCTGGGCAAGAAAAAACATCGGAGACGCCCCTCAAAGAAGAAGCGGCATTGGAAGCCCT
  ACTACAAGCTGACTTGGGAGGAGAAGAAAAAGTTCGACGAGAAGCAGAGCCTGCGAGCTTCGCGGGTTCG
  AGCCGAGATGTTCGCCAAGGGCCAGCCAGTTGCGCCCTATAACACCACGCAGTTCCTCATGGATGACCAC
  GATCAGGAGGAGCCTGATCTCAAAACCGGCCTTTACCCCAAGCGGGCAGCCGCCAAATCCGACGACACCA
  GCGATGAGGATTTTGTGGAAGAAGCTGGTGAGGAAGACGGAGGCAGCGATGGCATGGGAGGGGACGGCAG
  CGAGTTTCTGCAGCGGGACTTCTCGGAGACGTACGAGCGGTACCACGCCGAGAGCCTGCAGAACATGAGC
  AAGCAGGAGCTCATCAAAGAGTACCTGGAGCTGGAGAAGTGCCTCTCCCGCAAGGAGGACGAAAATAACC
  GGCTGCGGCTGGAAAGCAAGCGGCTGGGAGGCGTCGACGCGCGAGTGCGGGAGCTCGAGCTAGAGCTGGA
  CCGGCTGCGCGCTGAGAACCTCCAGCTGCTGACCGAGAACGAACTGCACCGGCAGCAGGAGCGAGCGCCT
  CTTTCCAAGTTCGGCGACTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_138753
• Insert Size: 1071 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_138753.2, NP_620092.1
• RefSeq Size: 3401 bp
• RefSeq ORF: 1071 bp
• Locus ID: 192231
• UniProt ID: Q8R409
• Cytogenetics: 11 E1
• Gene Summary: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.[UniProtKB/Swiss-Prot Function]