Tnfrsf10b (NM_020275) Mouse Untagged Clone

CAT#: MC207426

Tnfrsf10b (untagged) - Mouse tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Tnfrsf10b
• Synonyms: DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC207426 representing NM_020275
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGAGCCTCCAGGACCCAGCACGCCCACAGCCTCTGCCGCTGCCCGGGCAGATCACTACACCCCAGGCC
  TCCGGCCACTCCCGAAGCGCAGACTTCTATATAGCTTTGCGTTGCTGCTTGCTGTGCTACAGGCTGTCTT
  TGTTCCAGTAACAGCTAACCCAGCCCATAATCGTCCAGCTGGCCTACAGCGGCCGGAGGAGAGCCCATCA
  AGAGGACCCTGTCTAGCAGGCCAGTACCTGTCAGAAGGGAACTGCAAGCCTTGCAGAGAGGGTATTGACT
  ACACCAGCCATTCCAACCATTCTCTGGATTCATGTATTCTCTGCACAGTCTGTAAGGAAGATAAAGTCGT
  AGAAACCCGATGCAACATAACCACAAATACGGTGTGTCGATGCAAACCAGGCACCTTTGAAGATAAAGAC
  TCCCCTGAGATCTGCCAGTCATGCTCTAACTGCACTGACGGGGAAGAGGAACTGACTTCCTGTACCCCCA
  GAGAAAACCGGAAGTGTGTCTCCAAAACGGCTTGGGCATCTTGGCATAAGCTAGGCCTCTGGATAGGACT
  CCTGGTTCCAGTAGTGCTGCTGATTGGAGCTCTGCTTGTCTGGAAGACTGGAGCATGGAGGCAATGGTTG
  CTCTGTATAAAAAGAGGCTGTGAACGGGATCCCGAAAGTGCGAACTCTGTGCATTCGTCTCTCTTGGACC
  GACAGACATCTAGCACGACAAATGACTCTAACCACAACACGGAACCTGGCAAGACTCAGAAAACAGGAAA
  GAAGTTGCTGGTTCCGGTAAACGGAAACGACTCAGCTGACGACCTGAAGTTTATCTTCGAGTATTGTTCG
  GACATAGTGCCCTTTGACTCCTGGAACCGTCTCATGCGGCAGTTGGGCCTCACAGACAATCAAATCCAAA
  TGGTCAAAGCCGAAACACTGGTCACACGTGAGGCCCTGTACCAAATGCTGCTCAAGTGGCGCCACCAGAC
  TGGGCGAAGTGCCTCCATCAACCATCTGCTGGATGCCTTGGAAGCCGTGGAAGAGAGAGATGCCATGGAG
  AAAATTGAAGACTACGCAGTGAAATCCGGGAGGTTTACTTATCAGAACGCTGCAGCCCAACCAGAGACAG
  GGCCAGGAGGATCTCAGTGCGTTTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_020275
• Insert Size: 1146 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_020275.4, NP_064671.2
• RefSeq Size: 3197 bp
• RefSeq ORF: 1146 bp
• Locus ID: 21933
• UniProt ID: Q9QZM4
• Cytogenetics: 14 D2
• Gene Summary: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.[UniProtKB/Swiss-Prot Function]