MSH6 Mouse Monoclonal Antibody [Clone ID: UMAB258]
Carrier-free (BSA/glycerol-free) MSH6 mouse monoclonal antibody,clone UMAB258
Product Datasheet for 'UM800148CF'
Specifications
Product Data | |
Clone Name | UMAB258 |
Applications | IHC |
Recommend Dilution | IHC 1:50 |
Reactivity | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 1-280 of human MSH6(NP_000170) produced in E.coli. |
Formulation | PBS (pH7.3), 8% Trehalose |
Reconstitution Method | Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from cell culture supernatant by affinity chromatography |
Gene Name | Homo sapiens mutS homolog 6 (MSH6), transcript variant 1 |
Database Link | |
Background | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013] |
Synonyms | GTBP; GTMBP; HNPCC5; HSAP; p160 |
Reference Data | |
Protein Families | Druggable Genome, Stem cell - Pluripotency |
Protein Pathways | Colorectal cancer, Mismatch repair, Pathways in cancer |
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