IP10 (CXCL10) Rabbit Polyclonal Antibody
Rabbit Polyclonal CXCL10/INP10 Antibody
Product Datasheet for 'TA590731'
|Recommend Dilution||ELISA: 1:100-1:2000|
|Immunogen||DNA immunization. This antibody is specific for the entire range of the target protein.|
|Formulation||20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|Purification||The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.|
|Gene Name||C-X-C motif chemokine ligand 10|
|Background||The monoclonal antibody 6D4 recognizes human C-X-C motif chemokine 10 (IP-10), a protein of 98 amino acids. IP-10, also known as CXCL10, functions as ligand for the CXCR3 receptor. IP-10 belongs to the a-chemokine (C-X-C) family, which can be divided in two subfamilies: (1) potent chemoattractants for neutrophils, like IL-8 and (2) potent chemoattractants for lymphocytes, like the IFNg inducible protein (IP)-10. IP-10 is produced by a wide variety of cell types ranging from neutrophils, dendritic cells and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis, psoriasis and acute anterior uveitis. Various observations strongly suggest a role for the C-X-C chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis. Furthermore IP-10 is associated with acute rejection processes estimated by the predictive properties of urinary IP-10 expression for the short- and long-term graft function after kidney transplantation.|
|Synonyms||C7; crg-2; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10|
|Note||This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT|
|Protein Families||Druggable Genome, Secreted Protein, Transmembrane|
|Protein Pathways||Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway|
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