Cytochrome P450 2A6 (CYP2A6) Sheep Polyclonal Antibody

CAT#: TA353123L

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Sheep polyclonal anti-Cytochrome P450 2A6 antibody



USD 1,255.00


Availability*
5 Days

Size
    • 500 ul


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Specifications

Product Data
Recommended Dilution WB
Reactivity Human
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen CYP 2A6
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name cytochrome P450 family 2 subfamily A member 6
Background CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
Synonyms CPA6; CYP2A; CYP2A3; CYPIIA6; P450C2A; P450PB
Reference Data
Protein Families Druggable Genome, P450, Transmembrane
Protein Pathways Caffeine metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Retinol metabolism
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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